Adriana Costa-Ribeiro1, Ariadne Maux1, Thamyris Bosford1, Yumi Aoki1, Rebeca Castro1, Adriana Baltar1, Lívia Shirahige1, Alberto Moura Filho2, Michael A Nitsche3,4,5, Kátia Monte-Silva1. 1. a Department of Physical Therapy, Applied Neuroscience Laboratory , Universidade Federal de Pernambuco-UFPE , Pernambuco , Brazil. 2. b Department of Physical Therapy, Laboratory of Kinesiology and Functional Assessment , Universidade Federal de Pernambuco-UFPE , Pernambuco , Brazil. 3. c Department of Clinical Neurophysiology , Georg August University , Goettingen , Germany. 4. d Leibniz Research Centre for Working Environment and Human Resources , Dortmund , Germany. 5. e Department of Neurology , University Medical Hospital Bergmannsheil , Bochum , Germany.
Abstract
OBJECTIVE: The aim of this study is to investigate the effects of transcranial direct current stimulation (tDCS) combined with cueing gait training (CGT) on functional mobility in patients with Parkinson´s disease (PD). METHODS: A pilot double-blind controlled, randomized clinical trial was conducted with 22 patients with PD assigned to theexperimental (anodal tDCS plus CGT) and control group (sham tDCS plus CGT). The primary outcome (functional mobility) was assessed by 10-m walk test, cadence, stride length, and Timed Up and Go test. Motor impairment, bradykinesia, balance, and quality of life were analyzed as secondary outcomes. Minimal clinically important differences (MCIDs) were observed when assessing outcome data. RESULTS: Both groups demonstrated similar gains in all outcome measures, except for the stride length. The number of participants who showed MCID was similar between groups. CONCLUSION: The CGT provided many benefits to functional mobility, motor impairment, bradykinesia, balance, and quality of life. However, these effect magnitudes were not influenced by stimulation, but tDCS seems to prolong the effects of cueing therapy on functional mobility.
RCT Entities:
OBJECTIVE: The aim of this study is to investigate the effects of transcranial direct current stimulation (tDCS) combined with cueing gait training (CGT) on functional mobility in patients with Parkinson´s disease (PD). METHODS: A pilot double-blind controlled, randomized clinical trial was conducted with 22 patients with PD assigned to the experimental (anodal tDCS plus CGT) and control group (sham tDCS plus CGT). The primary outcome (functional mobility) was assessed by 10-m walk test, cadence, stride length, and Timed Up and Go test. Motor impairment, bradykinesia, balance, and quality of life were analyzed as secondary outcomes. Minimal clinically important differences (MCIDs) were observed when assessing outcome data. RESULTS: Both groups demonstrated similar gains in all outcome measures, except for the stride length. The number of participants who showed MCID was similar between groups. CONCLUSION: The CGT provided many benefits to functional mobility, motor impairment, bradykinesia, balance, and quality of life. However, these effect magnitudes were not influenced by stimulation, but tDCS seems to prolong the effects of cueing therapy on functional mobility.
Entities:
Keywords:
Functional mobility; Parkinson’s disease; gait training; transcranial direct current stimulation; visual cues
Authors: Jacqueline A Osborne; Rachel Botkin; Cristina Colon-Semenza; Tamara R DeAngelis; Oscar G Gallardo; Heidi Kosakowski; Justin Martello; Sujata Pradhan; Miriam Rafferty; Janet L Readinger; Abigail L Whitt; Terry D Ellis Journal: Phys Ther Date: 2022-04-01