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Literature DB >> 26863522

Cobalt-Catalyzed Bis-alkynylation of Amides via Double C-H Bond Activation.

Vinod G Landge^1,2, Garima Jaiswal^1,2, Ekambaram Balaraman^1,2.

Abstract

The first example of cobalt-catalyzed selective bis-alkynylation of amides via double C-H bond activation with the directing assistance of a removable bidentate auxiliary is reported. The developed alkynylation strategy is simple, efficient, and tolerant of various functional groups including ether, amine, halides, and heterocyclic motifs. The reaction can be scaled up under mild conditions.

Entities: Chemical

Year: 2016 PMID： 26863522 DOI： 10.1021/acs.orglett.6b00095

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

7 in total

1. Directing group assisted rhodium catalyzed meta-C-H alkynylation of arenes.

Authors: Sheuli Sasmal; Gaurav Prakash; Uttam Dutta; Ranjini Laskar; Goutam Kumar Lahiri; Debabrata Maiti
Journal: Chem Sci Date: 2022-04-20 Impact factor: 9.969

Review 2. A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.

Authors: Carlo Sambiagio; David Schönbauer; Remi Blieck; Toan Dao-Huy; Gerit Pototschnig; Patricia Schaaf; Thomas Wiesinger; Muhammad Farooq Zia; Joanna Wencel-Delord; Tatiana Besset; Bert U W Maes; Michael Schnürch
Journal: Chem Soc Rev Date: 2018-08-28 Impact factor: 54.564

3. Co-catalyzed ortho-C-H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs.

Authors: Cong Lin; Liang Shen
Journal: RSC Adv Date: 2019-09-26 Impact factor: 4.036

7. Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation.

Authors: Tjark H Meyer; João C A Oliveira; Debasish Ghorai; Lutz Ackermann
Journal: Angew Chem Int Ed Engl Date: 2020-05-05 Impact factor: 15.336

7 in total

Cobalt-Catalyzed Bis-alkynylation of Amides via Double C-H Bond Activation.

1. Directing group assisted rhodium catalyzed meta-C-H alkynylation of arenes.

Review 2. A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.

3. Co-catalyzed ortho-C-H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs.

4. Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups.

5. Nickel(ii)-catalyzed tandem C(sp²)-H bond activation and annulation of arenes with gem-dibromoalkenes.

6. Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination.

7. Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation.

Cobalt-Catalyzed Bis-alkynylation of Amides via Double C-H Bond Activation.

1. Directing group assisted rhodium catalyzed meta-C-H alkynylation of arenes.

Review 2. A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.

3. Co-catalyzed ortho-C-H functionalization/annulation of arenes and alkenes with alkynylsilanes: access to isoquinolone and pyridone motifs.

4. Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups.

5. Nickel(ii)-catalyzed tandem C(sp2)-H bond activation and annulation of arenes with gem-dibromoalkenes.

6. Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination.

7. Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation.

5. Nickel(ii)-catalyzed tandem C(sp²)-H bond activation and annulation of arenes with gem-dibromoalkenes.