Literature DB >> 26862113

Blood gene expression studies in migraine: Potential and caveats.

Zachary Gerring1, Astrid J Rodriguez-Acevedo1, Joseph E Powell2, Lyn R Griffiths3, Grant W Montgomery4, Dale R Nyholt5.   

Abstract

BACKGROUND: Global gene expression analysis may be used to obtain insights into the functional processes underlying migraine. However, there is a shortage of high-quality post-mortem brain tissue samples for genetic analysis. One approach is to use a more accessible tissue as a surrogate, such as peripheral blood.
PURPOSE: Discuss the benefits and caveats of blood genomic profiling in migraine and its potential application in the development of biomarkers of migraine susceptibility and outcome. Demonstrate the utility of blood-based expression profiles in migraine by analysing pilot Illumina HT-12 expression data from 76 (38 case, 38 control) whole-blood samples.
CONCLUSION: Current evidence suggests peripheral blood is a biologically valid substrate for genetic studies of migraine, and may be used to identify biomarkers and therapeutic pathways. Pilot blood gene expression data confirm that expression profiles significantly differ between migraine case and non-migraine control individuals. © International Headache Society 2016.

Entities:  

Keywords:  Migraine; association; biomarkers; blood; expression; gene; genomic profiling; mRNA

Mesh:

Substances:

Year:  2016        PMID: 26862113     DOI: 10.1177/0333102416628463

Source DB:  PubMed          Journal:  Cephalalgia        ISSN: 0333-1024            Impact factor:   6.292


  6 in total

Review 1.  A review of migraine genetics: gathering genomic and transcriptomic factors.

Authors:  Andreia Dias; Tiago Mariz; Alda Sousa; Carolina Lemos; Miguel Alves-Ferreira
Journal:  Hum Genet       Date:  2021-10-22       Impact factor: 4.132

Review 2.  Genetic and biochemical changes of the serotonergic system in migraine pathobiology.

Authors:  Claudia Francesca Gasparini; Robert Anthony Smith; Lyn Robyn Griffiths
Journal:  J Headache Pain       Date:  2017-02-13       Impact factor: 7.277

3.  Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine.

Authors:  Zachary F Gerring; Allan F McRae; Grant W Montgomery; Dale R Nyholt
Journal:  BMC Genomics       Date:  2018-01-22       Impact factor: 3.969

4.  Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action.

Authors:  Amit Anand; Kunio Nakamura; Jeffrey M Spielberg; Jungwon Cha; Harish Karne; Bo Hu
Journal:  Transl Psychiatry       Date:  2020-04-06       Impact factor: 6.222

5.  Integration of microarray data and literature mining identifies a sex bias in DPP4+CD4+ T cells in HIV-1 infection.

Authors:  Hans Christian Stubbe; Christine Dahlke; Katharina Rotheneder; Renate Stirner; Julia Roider; Raffaele Conca; Ulrich Seybold; Johannes Bogner; Marylyn Martina Addo; Rika Draenert
Journal:  PLoS One       Date:  2020-09-18       Impact factor: 3.240

6.  Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model.

Authors:  Timea Aczél; József Kun; Éva Szőke; Tibor Rauch; Sini Junttila; Attila Gyenesei; Kata Bölcskei; Zsuzsanna Helyes
Journal:  Front Mol Neurosci       Date:  2018-06-26       Impact factor: 5.639

  6 in total

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