AIMS: To study the relationship between the neoplastic cells of in situ lobular neoplasia (ILN) and ductal carcinoma in situ (DCIS) and the surrounding CD10-positive myoepithelial cells. MATERIALS AND METHODS: Twenty consecutive cases of ILN and 51 of DCIS were stained for CD10 using the immunoperoxidase technique. The presence of CD10-positive cells was assessed semiquantitatively on a scale of 0-3 where 0 indicates their absence and 3 indicates the presence of multiple layers, which can be focal. RESULTS: Ninety per cent of ILN cases scored 3, compared with none of DCIS (p=0.0001). There was a significant relationship between DCIS grade and CD10 score, with the mean scores being 1.43, 0.82 and 0.5 for low, intermediate and high grade, respectively. CD10-positive cells were always present around low-grade DCIS, but absent in 27% of high-grade cases. CD10-positive cells were more frequent in ER-positive than in ER-negative DCIS, and in HER2-negative than in HER2-positive cases, but the difference was not statistically significant. CONCLUSIONS: There is a distinct relationship between the type and grade of in situ neoplasia of the breast and the surrounding CD10-positive myoepithelial cells, suggesting the presence of a 'cross talk' between the two elements. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
AIMS: To study the relationship between the neoplastic cells of in situ lobular neoplasia (ILN) and ductal carcinoma in situ (DCIS) and the surrounding CD10-positive myoepithelial cells. MATERIALS AND METHODS: Twenty consecutive cases of ILN and 51 of DCIS were stained for CD10 using the immunoperoxidase technique. The presence of CD10-positive cells was assessed semiquantitatively on a scale of 0-3 where 0 indicates their absence and 3 indicates the presence of multiple layers, which can be focal. RESULTS: Ninety per cent of ILN cases scored 3, compared with none of DCIS (p=0.0001). There was a significant relationship between DCIS grade and CD10 score, with the mean scores being 1.43, 0.82 and 0.5 for low, intermediate and high grade, respectively. CD10-positive cells were always present around low-grade DCIS, but absent in 27% of high-grade cases. CD10-positive cells were more frequent in ER-positive than in ER-negative DCIS, and in HER2-negative than in HER2-positive cases, but the difference was not statistically significant. CONCLUSIONS: There is a distinct relationship between the type and grade of in situ neoplasia of the breast and the surrounding CD10-positive myoepithelial cells, suggesting the presence of a 'cross talk' between the two elements. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Entities:
Keywords:
BREAST; BREAST PATHOLOGY; IMMUNOHISTOCHEMISTRY
Authors: Lina Ding; Ying Su; Anne Fassl; Kunihiko Hinohara; Xintao Qiu; Nicholas W Harper; Sung Jin Huh; Noga Bloushtain-Qimron; Bojana Jovanović; Muhammad Ekram; Xiaoyuan Zi; William C Hines; Maša Alečković; Carlos Gil Del Alcazar; Ryan J Caulfield; Dennis M Bonal; Quang-De Nguyen; Vanessa F Merino; Sibgat Choudhury; Gabrielle Ethington; Laura Panos; Michael Grant; William Herlihy; Alfred Au; Gedge D Rosson; Pedram Argani; Andrea L Richardson; Deborah Dillon; D Craig Allred; Kirsten Babski; Elizabeth Min Hui Kim; Charles H McDonnell; Jon Wagner; Ron Rowberry; Kristie Bobolis; Celina G Kleer; E Shelley Hwang; Joanne L Blum; Simona Cristea; Piotr Sicinski; Rong Fan; Henry W Long; Saraswati Sukumar; So Yeon Park; Judy E Garber; Mina Bissell; Jun Yao; Kornelia Polyak Journal: Nat Commun Date: 2019-09-13 Impact factor: 14.919