Marissa J DeFreitas1, Wacharee Seeherunvong2, Chryso P Katsoufis2, Satish RamachandraRao3, Shahnaz Duara4, Salih Yasin5, Gaston Zilleruelo2, Maria M Rodriguez6, Carolyn L Abitbol2. 1. Division of Pediatric Nephrology, University of Miami/ Holtz Children's Hospital, 1611 NW 12th Avenue (Annex 504), Miami, FL, 33136, USA. mdefreitas@med.miami.edu. 2. Division of Pediatric Nephrology, University of Miami/ Holtz Children's Hospital, 1611 NW 12th Avenue (Annex 504), Miami, FL, 33136, USA. 3. O'Brien Center for AKI Research, UC San Diego School of Medicine, San Diego, CA, USA. 4. Division of Neonatology, University of Miami/Holtz Children's Hospital, Miami, FL, USA. 5. Division of Perinatology and Obstetrics, University of Miami/Holtz Children's Hospital, Miami, FL, USA. 6. Division of Pediatric Pathology, University of Miami/Holtz Children's Hospital, Miami, FL, USA.
Abstract
BACKGROUND: Urinary biomarkers may be indicators of acute kidney injury (AKI), although little is known of their developmental characteristics in healthy neonates across a full range of gestational age (GA). The purpose of this study was to examine patterns of urinary biomarkers across GA groups from birth to 3 months of age. METHODS: Fifty-two infants ranging from 24 to 41 weeks' GA had urine assayed from birth through 3 months of age for 7 biomarkers including albumin (ALB), beta-2-microglobulin (B2M), cystatin-C (CysC), epidermal growth factor (EGF), neutrophil-gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and uromodulin (UMOD). RESULTS: Of the seven urinary biomarkers, EGF and UMOD increased while others decreased with advancing GA. By 3 months of age, EGF and UMOD had increased in preterm infants to levels similar to those of term infants. UMOD/ml and EGF/ml appeared to be predominantly developmental biomarkers distinguishing estimated glomerular filtration rate (GFR) <30 ml/min/1.73 m(2) with receiver operator characteristic area under the curve (ROC-AUC) of 0.82; p = 0.002. When factored by urine creatinine CysC/cr + ALB/cr were the most significant functional markers with AUC = 0.79; p = 0.004; sensitivity 96 %; specificity 58 %. CONCLUSIONS: Among healthy neonates, urinary biomarkers vary with GA. These data support the use of urinary biomarkers in the assessment of normal kidney development in the absence of injury.
BACKGROUND: Urinary biomarkers may be indicators of acute kidney injury (AKI), although little is known of their developmental characteristics in healthy neonates across a full range of gestational age (GA). The purpose of this study was to examine patterns of urinary biomarkers across GA groups from birth to 3 months of age. METHODS: Fifty-two infants ranging from 24 to 41 weeks' GA had urine assayed from birth through 3 months of age for 7 biomarkers including albumin (ALB), beta-2-microglobulin (B2M), cystatin-C (CysC), epidermal growth factor (EGF), neutrophil-gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and uromodulin (UMOD). RESULTS: Of the seven urinary biomarkers, EGF and UMOD increased while others decreased with advancing GA. By 3 months of age, EGF and UMOD had increased in preterm infants to levels similar to those of term infants. UMOD/ml and EGF/ml appeared to be predominantly developmental biomarkers distinguishing estimated glomerular filtration rate (GFR) <30 ml/min/1.73 m(2) with receiver operator characteristic area under the curve (ROC-AUC) of 0.82; p = 0.002. When factored by urine creatinine CysC/cr + ALB/cr were the most significant functional markers with AUC = 0.79; p = 0.004; sensitivity 96 %; specificity 58 %. CONCLUSIONS: Among healthy neonates, urinary biomarkers vary with GA. These data support the use of urinary biomarkers in the assessment of normal kidney development in the absence of injury.
Authors: Maria M Rodríguez; Alexander H Gómez; Carolyn L Abitbol; Jayanthi J Chandar; Shahnaz Duara; Gastón E Zilleruelo Journal: Pediatr Dev Pathol Date: 2004 Jan-Feb
Authors: Carlton M Bates; Jennifer R Charlton; Maria E Ferris; Friedhelm Hildebrandt; Deborah K Hoshizaki; Bradley A Warady; Marva M Moxey-Mims Journal: Clin J Am Soc Nephrol Date: 2014-03-20 Impact factor: 8.237
Authors: Bohuslav Dvorak; Camellia C Fituch; Catherine S Williams; Nancy M Hurst; Richard J Schanler Journal: Pediatr Res Date: 2003-03-19 Impact factor: 3.756
Authors: Michael Zappitelli; Steven G Coca; Amit X Garg; Catherine D Krawczeski; Philbrook Thiessen Heather; Kyaw Sint; Simon Li; Chirag R Parikh; Prasad Devarajan Journal: Clin J Am Soc Nephrol Date: 2012-08-23 Impact factor: 8.237
Authors: Antonella Barbati; Maria Cristina Aisa; Benito Cappuccini; Mariarosalba Zamarra; Sandro Gerli; Gian Carlo Di Renzo Journal: Pediatr Res Date: 2020-05-18 Impact factor: 3.756
Authors: Christos P Argyropoulos; Shan Shan Chen; Yue-Harn Ng; Maria-Eleni Roumelioti; Kamran Shaffi; Pooja P Singh; Antonios H Tzamaloukas Journal: Front Med (Lausanne) Date: 2017-06-15
Authors: Anna Sellmer; Bodil H Bech; Jesper V Bjerre; Michael R Schmidt; Vibeke E Hjortdal; Gitte Esberg; Søren Rittig; Tine B Henriksen Journal: BMC Pediatr Date: 2017-01-10 Impact factor: 2.125
Authors: Yuri Levin-Schwartz; Paul Curtin; Katherine Svensson; Nicolas F Fernandez; Seunghee Kim-Schulze; Gleicy M Hair; Daniel Flores; Ivan Pantic; Marcela Tamayo-Ortiz; María Luisa Pizano-Zárate; Chris Gennings; Lisa M Satlin; Andrea A Baccarelli; Martha M Tellez-Rojo; Robert O Wright; Alison P Sanders Journal: PLoS One Date: 2019-12-31 Impact factor: 3.240