Junyoung Jo1, Myung Ja Kang2, Jin Moo Lee3, Hyunho Kim4, Ui Min Jerng5. 1. Department of Korean Gynecology, Graduate School, Kyung Hee University, Seoul 130-702, Republic of Korea; Department of Korean Gynecology, Conmaul Hospital, Seoul 137-881, Republic of Korea. Electronic address: studd@naver.com. 2. Department of Korean Gynecology, Conmaul Hospital, Seoul 137-881, Republic of Korea. Electronic address: womannature@naver.com. 3. Department of Korean Gynecology, Graduate School, Kyung Hee University, Seoul 130-702, Republic of Korea. Electronic address: hanbang9597@hanmail.net. 4. Department of Biofunctional Medicine & Diagnostics, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea. Electronic address: hyunho.kim@khu.ac.kr. 5. Clinical Research Division, Korea Institute of Oriental Medicine, Daejon 34054, Republic of Korea. Electronic address: breeze@kiom.re.kr.
Abstract
OBJECTIVE: The purpose of the present study is to retrospectively evaluate the effect of traditional Korean medicine (TKM) on ovarian reserve by measuring serum anti-Müllerian hormone (AMH) levels in patients with diminished ovarian reserve (DOR). STUDY DESIGN: We performed a retrospective chart review of patients with DOR who had received TKM for at least 2 months and had undergone serum AMH tests before and after TKM treatment. A total of 22 patients with DOR were included in the study. RESULTS: There were no significant differences in AMH levels before and after TKM in all patients (n=22, p=0.237). However, when the study population was divided into two age groups (<38 (n=12) and ≥38 years (n=10)) to determine whether there was a age-related difference in the effect of TKM with DOR, a significant increase in AMH levels before and after TKM was observed in the age <38 (p<0.05). CONCLUSIONS: TKM may provide an effective option for patients aged <38 years with DOR, but it should be interpreted cautiously as more rigorous research is needed. Further studies in a larger population are needed to confirm these results and to evaluate the effects of improved ovarian reserve on fertility outcomes following TKM in patients with DOR.
OBJECTIVE: The purpose of the present study is to retrospectively evaluate the effect of traditional Korean medicine (TKM) on ovarian reserve by measuring serum anti-Müllerian hormone (AMH) levels in patients with diminished ovarian reserve (DOR). STUDY DESIGN: We performed a retrospective chart review of patients with DOR who had received TKM for at least 2 months and had undergone serum AMH tests before and after TKM treatment. A total of 22 patients with DOR were included in the study. RESULTS: There were no significant differences in AMH levels before and after TKM in all patients (n=22, p=0.237). However, when the study population was divided into two age groups (<38 (n=12) and ≥38 years (n=10)) to determine whether there was a age-related difference in the effect of TKM with DOR, a significant increase in AMH levels before and after TKM was observed in the age <38 (p<0.05). CONCLUSIONS: TKM may provide an effective option for patients aged <38 years with DOR, but it should be interpreted cautiously as more rigorous research is needed. Further studies in a larger population are needed to confirm these results and to evaluate the effects of improved ovarian reserve on fertility outcomes following TKM in patients with DOR.
Authors: Tae-Young Choi; Ji Hee Jun; Hye Won Lee; Lin Ang; Eun Seop Kim; Ho Yeon Go; Sooseong You; Myeong Soo Lee Journal: Medicine (Baltimore) Date: 2019-11 Impact factor: 1.817