| Literature DB >> 26860777 |
Tao Luo1, Jin Kyung Kim2.
Abstract
Sex differences in the onset and manifestation of cardiovascular diseases are well known, yet the mechanism behind this discrepancy remains obscure. Estrogen and its corresponding receptors have been studied for their positive salutary effects in women for decades. Estrogen protects the heart from various forms of stress, including cytotoxic, ischemic, and hypertrophic stimuli. The postulated underlying mechanism is complex, and involves the actions of the hormone on the endothelium and myocardium. Although the effects of estrogen on the coronary endothelium are well-described, delineation of the hormone's action on cardiomyocytes is still evolving. The focus of this article is to review the accumulated literature and latest data on the role of estrogen and its receptors on cardiomyocytes, the contractile cellular units of the myocardium.Entities:
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Year: 2015 PMID： 26860777 PMCID： PMC4853290 DOI： 10.1016/j.cjca.2015.10.021
Source DB: PubMed Journal: Can J Cardiol ISSN： 0828-282X Impact factor: 5.223