Yu Zhang1, Jin Wei Qiang2, Yan Shen3, Jian Ding Ye4, Jie Zhang5, Lei Zhu5. 1. Department of Radiology, Jinshan Hospital & Shanghai Medical College, Fudan University, Shanghai 201508, China. 2. Department of Radiology, Jinshan Hospital & Shanghai Medical College, Fudan University, Shanghai 201508, China. Electronic address: dr.jinweiqiang@163.com. 3. Department of Radiology, Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China. 4. Department of Radiology, Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China. Electronic address: yejianding@126.com. 5. Department of Pathology, Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China.
Abstract
PURPOSE: To investigate the prevalence of multidetector CT (MDCT) air bronchograms and their value in predicting the invasiveness of lung adenocarcinomas. METHODS: MDCT scans of 606 nodules in 582 patients with a lung adenocarcinoma less than 2cm in diameter confirmed by surgery and pathology were reviewed. Air bronchograms were classified into three patterns: type I, bronchus with intact lumen; type II, bronchus with dilated or tortuous lumen; and type III, bronchus with obstructed lumen. RESULTS: Air bronchograms were demonstrated on MDCT in 210 of 606 (34.7%) lung adenocarcinomas with 16.6% (35/211) preinvasive lesions (PL), 30.5% (50/164) minimally invasive adenocarcinoma (MIA), and 54.1% (125/231) invasive adenocarcinoma (IAC) (P=0.000); 18.3% (44/240) pure ground-glass nodules (GGNs), 44.2% (137/310) mixed GGNs, and 51.8% (29/56) solid nodules (P=0.000). Type I was slightly more common in MIA (36/164, 22.0%) than IAC (40/231, 17.3%) and PL (30/211, 14.2%) but without differences among them (P=0.147). Type II (PL: 5/211, 2.4%; MIA: 13/164, 7.9%; IAC: 53/231, 22.9%) and type III (PL: 0/211; MIA: 1/164, 0.6%; IAC: 32/231, 13.9%) were observed more frequently with increasing lung adenocarcinoma invasiveness (both P=0.000). CONCLUSIONS: The prevalence and patterns of air bronchograms on MDCT can predict the invasiveness of small lung adenocarcinomas.
PURPOSE: To investigate the prevalence of multidetector CT (MDCT) air bronchograms and their value in predicting the invasiveness of lung adenocarcinomas. METHODS: MDCT scans of 606 nodules in 582 patients with a lung adenocarcinoma less than 2cm in diameter confirmed by surgery and pathology were reviewed. Air bronchograms were classified into three patterns: type I, bronchus with intact lumen; type II, bronchus with dilated or tortuous lumen; and type III, bronchus with obstructed lumen. RESULTS: Air bronchograms were demonstrated on MDCT in 210 of 606 (34.7%) lung adenocarcinomas with 16.6% (35/211) preinvasive lesions (PL), 30.5% (50/164) minimally invasive adenocarcinoma (MIA), and 54.1% (125/231) invasive adenocarcinoma (IAC) (P=0.000); 18.3% (44/240) pure ground-glass nodules (GGNs), 44.2% (137/310) mixed GGNs, and 51.8% (29/56) solid nodules (P=0.000). Type I was slightly more common in MIA (36/164, 22.0%) than IAC (40/231, 17.3%) and PL (30/211, 14.2%) but without differences among them (P=0.147). Type II (PL: 5/211, 2.4%; MIA: 13/164, 7.9%; IAC: 53/231, 22.9%) and type III (PL: 0/211; MIA: 1/164, 0.6%; IAC: 32/231, 13.9%) were observed more frequently with increasing lung adenocarcinoma invasiveness (both P=0.000). CONCLUSIONS: The prevalence and patterns of air bronchograms on MDCT can predict the invasiveness of small lung adenocarcinomas.
Authors: Maria D'Amato; Gaetano Rea; Vincenzo Carnevale; Maria Arcangela Grimaldi; Anna Rita Saponara; Eric Rosenthal; Michele Maria Maggi; Lucia Dimitri; Marco Sperandeo Journal: BMC Med Imaging Date: 2017-08-31 Impact factor: 1.930