Agnieszka Adamczyk1, Joanna Niemiec1, Aleksandra Ambicka2, Anna Mucha-Małecka3, Janusz Ryś2, Jerzy Mituś4, Wojciech M Wysocki4, Anna Cichocka1, Jerzy Jakubowicz3. 1. Department of Applied Radiobiology, Maria Sklodowska-Curie Memorial Cancer Centre & Institute of Oncology, Cracow Branch, 31-115 Cracow, Garncarska 11, Poland. 2. Department of Tumor Pathology, Maria Sklodowska-Curie Memorial Cancer Centre & Institute of Oncology, Cracow Branch, 31-115 Cracow, Garncarska 11, Poland. 3. Clinic of Oncology, Maria Sklodowska-Curie Memorial Cancer Centre & Institute of Oncology, Cracow Branch, 31-115 Cracow, Garncarska 11, Poland. 4. Department of Surgical Oncology, Maria Sklodowska-Curie Memorial Cancer Centre & Institute of Oncology, Cracow Branch, 31-115 Cracow, Garncarska 11, Poland.
Abstract
BACKGROUND: The differences between primary and metastatic tumor cells might be important for treatment selection and prognostication. MATERIALS & METHODS: Expression of ER, PR, HER2, CK5/6, EGFR, Ki-67, Ep-CAM, P-cadherin, CD24, CD44, ALDH was assessed immunohistochemically in primary tumor (T) and corresponding synchronous nodal metastases (LNM) in 156 invasive ductal breast cancer patients (T ≥1, N ≥1, M0). RESULTS: Independent negative prognostic factors for disease-free survival were pN3, ALDH immunopositivity in LNM, nonluminal A subtype in LNM, reduction of Ep-CAM expression in LNM, lack of changes or enhancement of CK5/6 and ALDH expression in LNM. DISCUSSION: Our results suggest that in some cases expression of markers in lymph node metastases might bring additional prognostic information to that obtained from primary tumor.
BACKGROUND: The differences between primary and metastatic tumor cells might be important for treatment selection and prognostication. MATERIALS & METHODS: Expression of ER, PR, HER2, CK5/6, EGFR, Ki-67, Ep-CAM, P-cadherin, CD24, CD44, ALDH was assessed immunohistochemically in primary tumor (T) and corresponding synchronous nodal metastases (LNM) in 156 invasive ductal breast cancerpatients (T ≥1, N ≥1, M0). RESULTS: Independent negative prognostic factors for disease-free survival were pN3, ALDH immunopositivity in LNM, nonluminal A subtype in LNM, reduction of Ep-CAM expression in LNM, lack of changes or enhancement of CK5/6 and ALDH expression in LNM. DISCUSSION: Our results suggest that in some cases expression of markers in lymph node metastases might bring additional prognostic information to that obtained from primary tumor.
Entities:
Keywords:
breast carcinoma; changes in proteins expression; lymph node metastases; primary tumor
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