Literature DB >> 26859828

Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial.

Jessica M Fogel1, Sarah E Hudelson, San-San Ou, Stephen Hart, Carole Wallis, Mariza G Morgado, Shanmugam Saravanan, Srikanth Tripathy, Laura Hovind, Estelle Piwowar-Manning, Devin Sabin, Marybeth McCauley, Theresa Gamble, Xinyi C Zhang, Joseph J Eron, Joel E Gallant, Johnstone Kumwenda, Joseph Makhema, Nagalingeswaran Kumarasamy, Suwat Chariyalertsak, James Hakim, Sharlaa Badal-Faesen, Victor Akelo, Mina C Hosseinipour, Breno R Santos, Sheela V Godbole, Jose H Pilotto, Beatriz Grinsztejn, Ravindre Panchia, Kenneth H Mayer, Ying Q Chen, Myron S Cohen, Susan H Eshleman.   

Abstract

Early initiation of antiretroviral treatment (ART) reduces HIV transmission and has health benefits. HIV drug resistance can limit treatment options and compromise use of ART for HIV prevention. We evaluated drug resistance in 85 participants in the HIV Prevention Trials Network 052 trial who started ART at CD4 counts of 350-550 cells per cubic millimeter and failed ART by May 2011; 8.2% had baseline resistance and 35.3% had resistance at ART failure. High baseline viral load and less education were associated with emergence of resistance at ART failure. Resistance at ART failure was observed in 7 of 8 (87.5%) participants who started ART at lower CD4 cell counts.

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Year:  2016        PMID： 26859828      PMCID： PMC4911290          DOI： 10.1097/QAI.0000000000000951

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  19 in total

1.  Undisclosed antiretroviral drug use in a multinational clinical trial (HIV Prevention Trials Network 052).

Authors:  Jessica M Fogel; Lei Wang; Teresa L Parsons; San-San Ou; Estelle Piwowar-Manning; Ying Chen; Victor O Mudhune; Mina C Hosseinipour; Johnstone Kumwenda; James G Hakim; Suwat Chariyalertsak; Ravindre Panchia; Ian Sanne; Nagalingeswaran Kumarasamy; Beatriz Grinsztejn; Joseph Makhema; Jose Pilotto; Breno R Santos; Kenneth H Mayer; Marybeth McCauley; Theresa Gamble; Namandjé N Bumpus; Craig W Hendrix; Myron S Cohen; Susan H Eshleman
Journal:  J Infect Dis       Date:  2013-08-01       Impact factor: 5.226

2.  Patterns of HIV-1 drug resistance after first-line antiretroviral therapy (ART) failure in 6 sub-Saharan African countries: implications for second-line ART strategies.

Authors:  Raph L Hamers; Kim C E Sigaloff; Annemarie M Wensing; Carole L Wallis; Cissy Kityo; Margaret Siwale; Kishor Mandaliya; Prudence Ive; Mariette E Botes; Maureen Wellington; Akin Osibogun; Wendy S Stevens; Tobias F Rinke de Wit; Rob Schuurman
Journal:  Clin Infect Dis       Date:  2012-04-03       Impact factor: 9.079

3.  Pretreatment HIV Drug Resistance and HIV-1 Subtype C Are Independently Associated With Virologic Failure: Results From the Multinational PEARLS (ACTG A5175) Clinical Trial.

Authors:  Rami Kantor; Laura Smeaton; Saran Vardhanabhuti; Sarah E Hudelson; Carol L Wallis; Srikanth Tripathy; Mariza G Morgado; Shanmugham Saravanan; Pachamuthu Balakrishnan; Marissa Reitsma; Stephen Hart; John W Mellors; Elias Halvas; Beatriz Grinsztejn; Mina C Hosseinipour; Johnstone Kumwenda; Alberto La Rosa; Umesh G Lalloo; Javier R Lama; Mohammed Rassool; Breno R Santos; Khuanchai Supparatpinyo; James Hakim; Timothy Flanigan; Nagalingeswaran Kumarasamy; Thomas B Campbell; Susan H Eshleman
Journal:  Clin Infect Dis       Date:  2015-02-13       Impact factor: 9.079

4.  Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial.

Authors:  Roy M Gulick; Heather J Ribaudo; Cecilia M Shikuma; Christina Lalama; Bruce R Schackman; William A Meyer; Edward P Acosta; Jeffrey Schouten; Kathleen E Squires; Christopher D Pilcher; Robert L Murphy; Susan L Koletar; Margrit Carlson; Richard C Reichman; Barbara Bastow; Karin L Klingman; Daniel R Kuritzkes
Journal:  JAMA       Date:  2006-08-16       Impact factor: 56.272

5.  Initiation of antiretroviral therapy at high CD4+ cell counts is associated with positive treatment outcomes.

Authors:  Viviane D Lima; Anja Reuter; P Richard Harrigan; Lillian Lourenço; William Chau; Mark Hull; Lauren Mackenzie; Silvia Guillemi; Robert S Hogg; Rolando Barrios; Julio S G Montaner
Journal:  AIDS       Date:  2015-09-10       Impact factor: 4.177

6.  Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

Authors:  Jens D Lundgren; Abdel G Babiker; Fred Gordin; Sean Emery; Birgit Grund; Shweta Sharma; Anchalee Avihingsanon; David A Cooper; Gerd Fätkenheuer; Josep M Llibre; Jean-Michel Molina; Paula Munderi; Mauro Schechter; Robin Wood; Karin L Klingman; Simon Collins; H Clifford Lane; Andrew N Phillips; James D Neaton
Journal:  N Engl J Med       Date:  2015-07-20       Impact factor: 91.245

7.  A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.

Authors:  Christine Danel; Raoul Moh; Delphine Gabillard; Anani Badje; Jérôme Le Carrou; Timothée Ouassa; Eric Ouattara; Amani Anzian; Jean-Baptiste Ntakpé; Albert Minga; Gérard M Kouame; Franck Bouhoussou; Arlette Emieme; Antoine Kouamé; André Inwoley; Thomas-d'Aquin Toni; Hugues Ahiboh; Mathieu Kabran; Cyprien Rabe; Baba Sidibé; Gustave Nzunetu; Romuald Konan; Joachim Gnokoro; Patrice Gouesse; Eugène Messou; Lambert Dohoun; Synali Kamagate; Abo Yao; Solange Amon; Amadou-Barenson Kouame; Aboli Koua; Emmanuel Kouamé; Yao Ndri; Olivier Ba-Gomis; Marcelle Daligou; Simplice Ackoundzé; Denise Hawerlander; Alex Ani; Fassery Dembélé; Fatoumata Koné; Calixte Guéhi; Constance Kanga; Serge Koule; Jonas Séri; Mykayila Oyebi; Nathalie Mbakop; Olewole Makaila; Carole Babatunde; Nathanael Babatounde; Gisèle Bleoué; Mireille Tchoutedjem; Alain-Claude Kouadio; Ghislaine Sena; Sahinou-Yediga Yededji; Rodrigue Assi; Alima Bakayoko; Alassane Mahassadi; Alain Attia; Armel Oussou; Max Mobio; Doféré Bamba; Mesmin Koman; Apollinaire Horo; Nina Deschamps; Henri Chenal; Madeleine Sassan-Morokro; Seidou Konate; Kakou Aka; Eba Aoussi; Valérie Journot; Célestin Nchot; Sophie Karcher; Marie-Laure Chaix; Christine Rouzioux; Papa-Salif Sow; Christian Perronne; Pierre-Marie Girard; Hervé Menan; Emmanuel Bissagnene; Auguste Kadio; Virginie Ettiegne-Traore; Corinne Moh-Semdé; Abo Kouame; Jean-Marie Massumbuko; Geneviève Chêne; Mireille Dosso; Serge K Domoua; Thérèse N'Dri-Yoman; Roger Salamon; Serge P Eholié; Xavier Anglaret
Journal:  N Engl J Med       Date:  2015-07-20       Impact factor: 91.245

8.  Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa.

Authors:  Vincent C Marconi; Henry Sunpath; Zhigang Lu; Michelle Gordon; Kofi Koranteng-Apeagyei; Jane Hampton; Steve Carpenter; Janet Giddy; Douglas Ross; Helga Holst; Elena Losina; Bruce D Walker; Daniel R Kuritzkes
Journal:  Clin Infect Dis       Date:  2008-05-15       Impact factor: 9.079

9.  Initiation of HAART at higher CD4 cell counts is associated with a lower frequency of antiretroviral drug resistance mutations at virologic failure.

Authors:  Jonathan Uy; Carl Armon; Kate Buchacz; Kathy Wood; John T Brooks
Journal:  J Acquir Immune Defic Syndr       Date:  2009-08-01       Impact factor: 3.731

10.  Role of HIV infection duration and CD4 cell level at initiation of combination anti-retroviral therapy on risk of failure.

Authors:  Sara Lodi; Andrew Phillips; Sarah Fidler; David Hawkins; Richard Gilson; Ken McLean; Martin Fisher; Frank Post; Anne M Johnson; Louise Walker-Nthenda; David Dunn; Kholoud Porter
Journal:  PLoS One       Date:  2013-09-24       Impact factor: 3.240
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  9 in total

1.  HIV Drug Resistance in Adults Receiving Early vs. Delayed Antiretroviral Therapy: HPTN 052.

Authors:  Philip J Palumbo; Jessica M Fogel; Sarah E Hudelson; Ethan A Wilson; Stephen Hart; Laura Hovind; Estelle Piwowar-Manning; Carole Wallis; Maria A Papathanasopoulos; Mariza G Morgado; Shanmugam Saravanan; Srikanth Tripathy; Joseph J Eron; Joel E Gallant; Marybeth McCauley; Theresa Gamble; Mina C Hosseinipour; Nagalingeswaran Kumarasamy; James G Hakim; Jose H Pilotto; Johnstone Kumwenda; Victor Akelo; Sheela V Godbole; Breno R Santos; Beatriz Grinsztejn; Ravindre Panchia; Suwat Chariyalertsak; Joseph Makhema; Sharlaa Badal-Faesen; Ying Q Chen; Myron S Cohen; Susan H Eshleman
Journal:  J Acquir Immune Defic Syndr       Date:  2018-04-15       Impact factor: 3.731

2.  Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses.

Authors:  Stella J Berendam; Tiffany M Styles; Rama R Amara; Genevieve G Fouda; Papa K Morgan-Asiedu; DeAnna Tenney; Amit Kumar; Veronica Obregon-Perko; Katharine J Bar; Kevin O Saunders; Sampa Santra; Kristina De Paris; Georgia D Tomaras; Ann Chahroudi; Sallie R Permar
Journal:  J Virol       Date:  2021-01-13       Impact factor: 5.103

3.  Recovering Infectious HIV from Novel Syringe-Needle Combinations with Low Dead Space Volumes.

Authors:  Nadia Abdala; Amisha Patel; Robert Heimer
Journal:  AIDS Res Hum Retroviruses       Date:  2016-08-22       Impact factor: 2.205

Review 4.  Host and Viral Factors Influencing Interplay between the Macrophage and HIV-1.

Authors:  Viviane Machado Andrade; Mario Stevenson
Journal:  J Neuroimmune Pharmacol       Date:  2018-07-11       Impact factor: 4.147

5.  Same day ART initiation versus clinic-based pre-ART assessment and counselling for individuals newly tested HIV-positive during community-based HIV testing in rural Lesotho - a randomized controlled trial (CASCADE trial).

Authors:  Niklaus Daniel Labhardt; Isaac Ringera; Thabo Ishmael Lejone; Phofu Masethothi; T'sepang Thaanyane; Mashaete Kamele; Ravi Shankar Gupta; Kyaw Thin; Bernard Cerutti; Thomas Klimkait; Christiane Fritz; Tracy Renée Glass
Journal:  BMC Public Health       Date:  2016-04-14       Impact factor: 3.295

6.  Behavioral Intention to Initiate Antiretroviral Therapy (ART) Among Chinese HIV-Infected Men Who Have Sex With Men Having High CD4 Count in the Era of "Treatment for All".

Authors:  Xueying Yang; Zixin Wang; Xiaodong Wang; Tiecheng Ma; Honghong Xue; Yingqin He; Joseph Tak Fai Lau
Journal:  Am J Mens Health       Date:  2019 Jan-Feb

7.  Drug Resistance in HIV-Positive Adults During the Initial Year of Antiretroviral Treatment at Ethiopian Health Centers.

Authors:  Anton Reepalu; Dawit A Arimide; Taye T Balcha; Habtamu Yeba; Adinew Zewdu; Patrik Medstrand; Per Björkman
Journal:  Open Forum Infect Dis       Date:  2021-03-06       Impact factor: 3.835

8.  HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016.

Authors:  Jiayi Chen; Yang Liu; Sijing Liu; Dan Yuan; Ling Su; Li Ye; Fanghong Gong; Yushuang Gao; Saira Baloch; Xiaofang Pei
Journal:  Biomed Res Int       Date:  2020-03-23       Impact factor: 3.411

9.  Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV.

Authors:  Oliver T Stirrup; Caroline A Sabin; Andrew N Phillips; Ian Williams; Duncan Churchill; Anna Tostevin; Teresa Hill; David T Dunn
Journal:  J Virus Erad       Date:  2019-11-04
  9 in total

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