Neuropharmacological effects of nicotine in relation to cholinergic mechanisms.

Studies with nicotine have, from the outset, been of fundamental importance for the elucidation of physiological mechanisms. However, many nicotinic cholinoreceptors do not appear to subserve a physiological role, at least within the present framework of knowledge. The main challenge in the immediate future is to determine the functional role of nicotinic cholinoceptors in the CNS. This knowledge will not only add to the physiological mechanisms that have been unravelled as a result of studies with nicotine, but will also provide a major contribution to the understanding of tobacco use.