Doris P Yimgang1, Evelise Brizola1,2, Jay R Shapiro1. 1. a Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine , Baltimore , MD , USA and. 2. b Post Graduate Program in Child and Adolescent Health, Faculty of Medicine, Federal University of Rio Grande Do Sul , Porto Alegre , Brazil.
Abstract
OBJECTIVE: To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI). STUDY DESIGN: A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child's clinical information including OI type, height and weight. RESULTS: Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission. CONCLUSION: Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.
OBJECTIVE: To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI). STUDY DESIGN: A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child's clinical information including OI type, height and weight. RESULTS: Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission. CONCLUSION: Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.
Authors: Allison Tam; Shan Chen; Evan Schauer; Ingo Grafe; Venkata Bandi; Jay R Shapiro; Robert D Steiner; Peter A Smith; Michael B Bober; Tracy Hart; David Cuthbertson; Jeffrey Krischer; Mary Mullins; Peter H Byers; Robert A Sandhaus; Michaela Durigova; Francis H Glorieux; Frank Rauch; Vernon Reid Sutton; Brendan Lee; Eric T Rush; Sandesh C S Nagamani Journal: Clin Genet Date: 2018-09-24 Impact factor: 4.438
Authors: Laura L Tosi; Marianne K Floor; Christina M Dollar; Austin P Gillies; Tracy S Hart; David D Cuthbertson; V Reid Sutton; Jeffrey P Krischer Journal: Orphanet J Rare Dis Date: 2019-01-29 Impact factor: 4.123