| Literature DB >> 26856236 |
Elizabeth Ing-Simmons1, Matthias Merkenschlager2.
Abstract
A recent article makes a compelling case for a new mechanism by which heterozygous mutations in isocitrate dehydrogenases (IDH1/2)--implicated in cancer--undermine gene regulation. 2-Hydroxyglutarate (2HG) produced by mutant IDH alters the binding of the chromosomal organizer protein CTCF, disrupting the spatial and regulatory organization of the genome.Entities:
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Year: 2016 PMID： 26856236 DOI： 10.1016/j.molmed.2016.01.008
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951