| Literature DB >> 2685576 |
M Moyle1, J S Lee, W F Anderson, C J Ingles.
Abstract
Monoclonal antibodies specific for the evolutionarily conserved C-terminal heptapeptide repeat domain of the largest subunit of RNA polymerase II inhibited the initiation of transcription from mammalian promoters in vitro. Since these antibodies did not inhibit elongation and randomly initiated transcription, the heptapeptide repeats may function by binding class II transcription initiation factor(s).Entities:
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Year: 1989 PMID: 2685576 PMCID: PMC363751 DOI: 10.1128/mcb.9.12.5750-5753.1989
Source DB: PubMed Journal: Mol Cell Biol ISSN: 0270-7306 Impact factor: 4.272