Literature DB >> 26854981

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides.

Yi-ning Wen1, Zhi-feng Zhang1, Ning-ning Liu1, Yu-hong Xiang2, Zhuo-yong Zhang2, Graciela Andrei3, Robert Snoeck3, Dominique Schols3, Qing-shan Zhang1, Qin-pei Wu1.   

Abstract

A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

Entities:  

Keywords:  Huisgen 1,3-dipolar cycloaddition; antiviral; nucleosides; triazole

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Year:  2016        PMID： 26854981     DOI： 10.1080/15257770.2015.1115523

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  1 in total

1.  Design, Modeling and Synthesis of 1,2,3-Triazole-Linked Nucleoside-Amino Acid Conjugates as Potential Antibacterial Agents.

Authors:  Sarah N Malkowski; Carolyn F Dishuck; Gene G Lamanilao; Carter P Embry; Christopher S Grubb; Mauricio Cafiero; Larryn W Peterson
Journal:  Molecules       Date:  2017-10-10       Impact factor: 4.411
  1 in total

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