Litong Ji1, Tie Wang2, Lining Tian3, Meizhuo Gao4. 1. The Department of General Surgery, The Forth Affiliated Hospital of Harbin Medical University, Harbin, China. 2. The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, China. 3. The Department of Medical Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China. 4. The Department of General Surgery, The Forth Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: Dr.MZGao@outlook.com.
Abstract
BACKGROUND/AIMS: The incidence of esophagogastric junction (EGJ) carcinoma has increased worldwide. The only curable strategy for EGJ carcinoma is surgery, whereas anastomotic leakage is the major complication after operations. We aimed to test whether the serum levels of C-reactive protein have the diagnostic value for anastomotic leakage after surgery for EGJ carcinoma. METHODS: In this study, we analyzed the values of CRP before and 5 continuous days after surgery in 97 EGJ carcinoma patients who received surgery as the initial treatment. The levels of CRP in the groups of EGJ patients with or without anastomotic leakage were compared. RESULTS: The CRP levels of patients with anastomotic leakage elevated faster and remained higher compared patients without anastomotic leakage. The CRP value at Day 2 after radical surgery for EGJ carcinoma patients has the early diagnostic value for anastomotic leakage. The cut-off value of CRP for anastomotic leakage at Day 2 is 177 mg/l with the sensitivity of 0.9 and specificity of 0.95 (P < 0.0001). CONCLUSION: Surgical EGJ carcinoma patients with elevated CRP at Day 2 after surgery should be excluded the possibility of anastomotic leakage.
BACKGROUND/AIMS: The incidence of esophagogastric junction (EGJ) carcinoma has increased worldwide. The only curable strategy for EGJ carcinoma is surgery, whereas anastomotic leakage is the major complication after operations. We aimed to test whether the serum levels of C-reactive protein have the diagnostic value for anastomotic leakage after surgery for EGJ carcinoma. METHODS: In this study, we analyzed the values of CRP before and 5 continuous days after surgery in 97 EGJ carcinomapatients who received surgery as the initial treatment. The levels of CRP in the groups of EGJ patients with or without anastomotic leakage were compared. RESULTS: The CRP levels of patients with anastomotic leakage elevated faster and remained higher compared patients without anastomotic leakage. The CRP value at Day 2 after radical surgery for EGJ carcinomapatients has the early diagnostic value for anastomotic leakage. The cut-off value of CRP for anastomotic leakage at Day 2 is 177 mg/l with the sensitivity of 0.9 and specificity of 0.95 (P < 0.0001). CONCLUSION: Surgical EGJ carcinomapatients with elevated CRP at Day 2 after surgery should be excluded the possibility of anastomotic leakage.
Authors: Bruno A Messias; Ricardo V Botelho; Sarhan S Saad; Erica R Mocchetti; Karine C Turke; Jaques Waisberg Journal: Sci Rep Date: 2020-02-03 Impact factor: 4.379