To the Editor,Many thanks to the author for their important comments to our paper entitled “High levels of HB-EGF and interleukin-18 are associated with a high risk of in-stent restenosis” published in Anatolian Journal of Cardiology 2015; 15: 907-12 (1). In the study, we demonstrated that HB-EGF may be used to evaluate the severities of restenosis and coronary artery lesion and inflammatory responses may involve in the process of restenosis.First, we collected data including demographic characteristics, medical history, location of the vascular stenosis, severity and type of the stenosis, location of the stent implantation, type of the stent, type of the balloon, blood flow grade (TIMI), time of coronary angiography, in-stent restenosis and its location, de novo stenosis, and second stent implantation (1).The effect of regular exercise training was not evaluated (2). We agree this factor can provide complementary information. Therefore, this factor needs to be considered in future studies.