| Literature DB >> 26854352 |
Mikako Kato1, Mostafa A S Hammam1, Tohru Taniguchi1, Yoshiko Suga1, Kenji Monde1.
Abstract
D609 (1) has been used as a lipid-related enzyme inhibitor during the past three decades. Although it has eight possible stereoisomers, no systematic research considering its chirality has been performed. In this paper, eight possible chiral alcohols as direct precursors of D609 were synthesized, and their stereochemistries were elucidated by a vibrational circular dichroism (VCD) technique. Phosphatidylcholine-specific phospholipase C and sphingomyelin synthase inhibition assays of these isomers showed considerable differences in their activities.Entities:
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Year: 2016 PMID： 26854352 DOI： 10.1021/acs.orglett.6b00025
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005