H R Harris1, J F Simard2, E V Arkema3. 1. Division of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA holly.harris@ki.se. 2. Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden Division of Epidemiology, Department of Health Research and Policy, Stanford School of Medicine, Stanford, USA Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, USA. 3. Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
Abstract
OBJECTIVE: To investigate the association between endometriosis and systemic lupus erythematosus (SLE) in prospectively collected population-based data. METHODS: We conducted a case-control study using Swedish registers, identifying female SLE cases from the National Patient Register and female controls sampled from the general population matched on birth year, sex and county during 1964-2011. We identified endometriosis diagnoses from the National Patient Register using ICD codes. We estimated odds ratios and 95% confidence intervals using conditional logistic regression models. RESULTS: We identified 2834 cases of SLE and 14,164 controls. Seventy-eight cases were diagnosed with endometriosis prior to their SLE diagnosis and 288 controls were diagnosed prior to the index date. We observed a significant association between endometriosis and subsequent SLE with an odds ratio of 1.39 (95% confidence interval = 1.09-1.78). The association was similar when requiring a laparoscopy/laparotomy within six months of the endometriosis diagnosis (odds ratio = 1.33; 95% confidence interval = 0.84-2.12) while the association was stronger when restricted to endometriosis diagnosed at the same time as hysterectomy (odds ratio = 2.26; 95% confidence interval = 1.47-3.64). CONCLUSIONS: Our findings suggest an association between endometriosis and SLE. Future prospective studies with extended follow-up will be necessary to clarify whether this association is influenced by the timing and severity of endometriosis diagnosis.
OBJECTIVE: To investigate the association between endometriosis and systemic lupus erythematosus (SLE) in prospectively collected population-based data. METHODS: We conducted a case-control study using Swedish registers, identifying female SLE cases from the National Patient Register and female controls sampled from the general population matched on birth year, sex and county during 1964-2011. We identified endometriosis diagnoses from the National Patient Register using ICD codes. We estimated odds ratios and 95% confidence intervals using conditional logistic regression models. RESULTS: We identified 2834 cases of SLE and 14,164 controls. Seventy-eight cases were diagnosed with endometriosis prior to their SLE diagnosis and 288 controls were diagnosed prior to the index date. We observed a significant association between endometriosis and subsequent SLE with an odds ratio of 1.39 (95% confidence interval = 1.09-1.78). The association was similar when requiring a laparoscopy/laparotomy within six months of the endometriosis diagnosis (odds ratio = 1.33; 95% confidence interval = 0.84-2.12) while the association was stronger when restricted to endometriosis diagnosed at the same time as hysterectomy (odds ratio = 2.26; 95% confidence interval = 1.47-3.64). CONCLUSIONS: Our findings suggest an association between endometriosis and SLE. Future prospective studies with extended follow-up will be necessary to clarify whether this association is influenced by the timing and severity of endometriosis diagnosis.
Authors: Nete Munk Nielsen; Kristian T Jørgensen; Bo V Pedersen; Klaus Rostgaard; Morten Frisch Journal: Hum Reprod Date: 2011-04-06 Impact factor: 6.918
Authors: Holly R Harris; Karen H Costenbader; Fan Mu; Marina Kvaskoff; Susan Malspeis; Elizabeth W Karlson; Stacey A Missmer Journal: Ann Rheum Dis Date: 2015-08-03 Impact factor: 19.103
Authors: Jonas F Ludvigsson; Eva Andersson; Anders Ekbom; Maria Feychting; Jeong-Lim Kim; Christina Reuterwall; Mona Heurgren; Petra Otterblad Olausson Journal: BMC Public Health Date: 2011-06-09 Impact factor: 3.295
Authors: Amy L Shafrir; Marissa C Palmor; Jessica Fourquet; Amy D DiVasta; Leslie V Farland; Allison F Vitonis; Holly R Harris; Marc R Laufer; Daniel W Cramer; Kathryn L Terry; Stacey A Missmer Journal: Am J Reprod Immunol Date: 2021-02-25 Impact factor: 3.777