| Literature DB >> 26853480 |
Xingxing Li1, Xuan Lei1, Cong Zhang1, Zhibo Jiang1, Yuanyuan Shi1, Songmei Wang1, Lifei Wang2, Bin Hong3.
Abstract
Streptomyces globisporus C-1027 produces a nine-membered enediyne antitumor antibiotic lidamycin. Here we report the complete genome sequence of S. globisporus C-1027, which consists of a 7,608,611 bp linear chromosome, a 167,754 bp linear plasmid SGLP1 and a 7,234 bp circular plasmid pSGL1. The biosynthetic gene cluster for lidamycin was located in the linear plasmid SGLP1. Genome analysis also revealed a number of genes related to biosynthesis of diverse secondary metabolites. The genome sequence of C-1027 will enable us to disclose biosynthetic pathways of these secondary metabolites and discover new natural products with potential applications notably in human health.Entities:
Keywords: Genome sequence; Lidamycin; Streptomyces globisporus C-1027
Mesh：
Substances：
Year: 2016 PMID： 26853480 DOI： 10.1016/j.jbiotec.2016.02.004
Source DB: PubMed Journal: J Biotechnol ISSN： 0168-1656 Impact factor: 3.307