Mirna Azar1, Majid Nikpay2, Mary-Ellen Harper3, Ruth McPherson2, Robert Dent1. 1. The Ottawa Hospital Weight Management Clinic, Ottawa, Canada. 2. Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada. 3. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.
Abstract
OBJECTIVE: To determine whether weight loss (WL) with 6 weeks of a low-calorie liquid diet as part of a behavioral program (LCDBP) predicts subsequent weight change in response to a laparoscopic Roux-en-Y gastric bypass (RYGB). METHODS: Of 4698 LCDBP patients, 403 went on to RYGB and 222 were evaluable. We determined correlations between percent WL (% WL) in 6 weeks of LCDBP with % WL at 4, 12, 24, 36, and 52 weeks after RYGB. RESULTS: There was a positive correlation between the slope of WL in the first 6 weeks of LCDBP and over 4 and 12 weeks after RYGB: r = 0.15 (CI = 0.003-0.285, P = 0.045) and r = 0.22 (CI = 0.08-0.35, P = 0.0017), respectively. The association was also apparent at 24 weeks in females but not in males. There was a statistically significant correlation between % WL at 26 weeks of LCDBP and 52 weeks postsurgery (r = 0.20, CI = 0.05-0.34, P = 0.01). Finally, % WL at 6 weeks also predicted % WL at 26 weeks of dietary intervention (r = 0.52, CI = 0.40-0.62, P = 2.40 × 10(-14) ). CONCLUSIONS: WL in response to 6 weeks of LCDBP is predictive of weight for at least 12 weeks following RYGB.
OBJECTIVE: To determine whether weight loss (WL) with 6 weeks of a low-calorie liquid diet as part of a behavioral program (LCDBP) predicts subsequent weight change in response to a laparoscopic Roux-en-Y gastric bypass (RYGB). METHODS: Of 4698 LCDBPpatients, 403 went on to RYGB and 222 were evaluable. We determined correlations between percent WL (% WL) in 6 weeks of LCDBP with % WL at 4, 12, 24, 36, and 52 weeks after RYGB. RESULTS: There was a positive correlation between the slope of WL in the first 6 weeks of LCDBP and over 4 and 12 weeks after RYGB: r = 0.15 (CI = 0.003-0.285, P = 0.045) and r = 0.22 (CI = 0.08-0.35, P = 0.0017), respectively. The association was also apparent at 24 weeks in females but not in males. There was a statistically significant correlation between % WL at 26 weeks of LCDBP and 52 weeks postsurgery (r = 0.20, CI = 0.05-0.34, P = 0.01). Finally, % WL at 6 weeks also predicted % WL at 26 weeks of dietary intervention (r = 0.52, CI = 0.40-0.62, P = 2.40 × 10(-14) ). CONCLUSIONS: WL in response to 6 weeks of LCDBP is predictive of weight for at least 12 weeks following RYGB.
Authors: Chantal A Pileggi; Breana G Hooks; Ruth McPherson; Robert R M Dent; Mary-Ellen Harper Journal: Clin Sci (Lond) Date: 2022-07-29 Impact factor: 6.876
Authors: A B Thrush; G Antoun; M Nikpay; D A Patten; C DeVlugt; J-F Mauger; B L Beauchamp; P Lau; R Reshke; É Doucet; P Imbeault; R Boushel; D Gibbings; J Hager; A Valsesia; R S Slack; O Y Al-Dirbashi; R Dent; R McPherson; M-E Harper Journal: Int J Obes (Lond) Date: 2017-11-20 Impact factor: 5.095