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Literature DB >> 26852268

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense.

Aryn A Price¹, Arash Grakoui², David S Weiss³.

Abstract

Clustered, regularly interspaced, short palindromic repeats - CRISPR-associated (CRISPR-Cas) systems - are sequence-specific RNA-directed endonuclease complexes that bind and cleave nucleic acids. These systems evolved within prokaryotes as adaptive immune defenses to target and degrade nucleic acids derived from bacteriophages and other foreign genetic elements. The antiviral function of these systems has now been exploited to combat eukaryotic viruses throughout the viral life cycle. Here we discuss current advances in CRISPR-Cas9 technology as a eukaryotic antiviral defense.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Cas9; HBV; HCV; HIV; antiviral; virus

Mesh：

Year: 2016 PMID： 26852268 PMCID： PMC4808413 DOI： 10.1016/j.tim.2016.01.005

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

110 in total

1. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

Authors: F Ann Ran; Patrick D Hsu; Chie-Yu Lin; Jonathan S Gootenberg; Silvana Konermann; Alexandro E Trevino; David A Scott; Azusa Inoue; Shogo Matoba; Yi Zhang; Feng Zhang
Journal: Cell Date: 2013-08-29 Impact factor: 41.582

2. Rational design of a split-Cas9 enzyme complex.

Authors: Addison V Wright; Samuel H Sternberg; David W Taylor; Brett T Staahl; Jorge A Bardales; Jack E Kornfeld; Jennifer A Doudna
Journal: Proc Natl Acad Sci U S A Date: 2015-02-23 Impact factor: 11.205

Review 3. Retroviral DNA integration.

Authors: A T Panganiban
Journal: Cell Date: 1985-08 Impact factor: 41.582

Review 4. Targeting hepatitis B virus cccDNA using CRISPR/Cas9.

Authors: Edward M Kennedy; Anand V R Kornepati; Bryan R Cullen
Journal: Antiviral Res Date: 2015-10-22 Impact factor: 5.970

5. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.

Authors: Hsin-Kai Liao; Ying Gu; Arturo Diaz; John Marlett; Yuta Takahashi; Mo Li; Keiichiro Suzuki; Ruo Xu; Tomoaki Hishida; Chan-Jung Chang; Concepcion Rodriguez Esteban; John Young; Juan Carlos Izpisua Belmonte
Journal: Nat Commun Date: 2015-03-10 Impact factor: 14.919

6. Phage response to CRISPR-encoded resistance in Streptococcus thermophilus.

Authors: Hélène Deveau; Rodolphe Barrangou; Josiane E Garneau; Jessica Labonté; Christophe Fremaux; Patrick Boyaval; Dennis A Romero; Philippe Horvath; Sylvain Moineau
Journal: J Bacteriol Date: 2007-12-07 Impact factor: 3.490

7. The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo.

Authors: Su-Ru Lin; Hung-Chih Yang; Yi-Ting Kuo; Chun-Jen Liu; Ta-Yu Yang; Ku-Chun Sung; You-Yu Lin; Hurng-Yi Wang; Chih-Chiang Wang; Yueh-Chi Shen; Fang-Yi Wu; Jia-Horng Kao; Ding-Shinn Chen; Pei-Jer Chen
Journal: Mol Ther Nucleic Acids Date: 2014-08-19 Impact factor: 10.183

8. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos.

Authors: Nannan Chang; Changhong Sun; Lu Gao; Dan Zhu; Xiufei Xu; Xiaojun Zhu; Jing-Wei Xiong; Jianzhong Jeff Xi
Journal: Cell Res Date: 2013-03-26 Impact factor: 25.617

9. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.

Authors: Yanfang Fu; Jeffry D Sander; Deepak Reyon; Vincent M Cascio; J Keith Joung
Journal: Nat Biotechnol Date: 2014-01-26 Impact factor: 54.908

10. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

Authors: Pablo Perez-Pinera; D Dewran Kocak; Christopher M Vockley; Andrew F Adler; Ami M Kabadi; Lauren R Polstein; Pratiksha I Thakore; Katherine A Glass; David G Ousterout; Kam W Leong; Farshid Guilak; Gregory E Crawford; Timothy E Reddy; Charles A Gersbach
Journal: Nat Methods Date: 2013-07-25 Impact factor: 28.547

10 in total

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense.

1. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

2. Rational design of a split-Cas9 enzyme complex.

Review 3. Retroviral DNA integration.

Review 4. Targeting hepatitis B virus cccDNA using CRISPR/Cas9.

5. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.

6. Phage response to CRISPR-encoded resistance in Streptococcus thermophilus.

7. The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo.

8. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos.

9. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.

10. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

1. HIV-1 Employs Multiple Mechanisms To Resist Cas9/Single Guide RNA Targeting the Viral Primer Binding Site.

Review 2. Genome-editing approaches and applications: a brief review on CRISPR technology and its role in cancer.

3. CRISPR/Cas9: a double-edged sword when used to combat HIV infection.

Review 4. Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape.

Review 5. Antiviral Defenses in Plants through Genome Editing.

6. Establishing RNA virus resistance in plants by harnessing CRISPR immune system.

Review 7. Engineering plant virus resistance: from RNA silencing to genome editing strategies.

8. Production of CFTR-ΔF508 Rabbits.

9. Engineering CRISPR immune systems conferring GLRaV-3 resistance in grapevine.

10. CRISPR-Cas13d mediates robust RNA virus interference in plants.