Literature DB >> 26852256

Pubertal development and regulation.

Ana Paula Abreu1, Ursula B Kaiser2.   

Abstract

Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by a complex network of excitatory and inhibitory factors. This axis is active in the embryonic and early postnatal stages of life and is subsequently restrained during childhood, and its reactivation culminates in puberty initiation. The mechanisms underlying this reactivation are not completely known. The age of puberty onset varies between individuals and the timing of puberty initiation is associated with several health outcomes in adult life. In this Series paper, we discuss pubertal markers, epidemiological trends of puberty initiation over time, and the mechanisms whereby genetic, metabolic, and other factors control secretion of gonadotropin-releasing hormone to determine initiation of puberty.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 26852256      PMCID： PMC5192018          DOI： 10.1016/S2213-8587(15)00418-0

Source DB:  PubMed          Journal:  Lancet Diabetes Endocrinol        ISSN： 2213-8587            Impact factor:   32.069


  113 in total

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  94 in total

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9.  Central Precocious Puberty Caused by a Heterozygous Deletion in the MKRN3 Promoter Region.

Authors:  Delanie B Macedo; Monica M França; Luciana R Montenegro; Marina Cunha-Silva; Danielle S Best; Ana Paula Abreu; Ursula B Kaiser; Berenice B Mendonca; Alexander A L Jorge; Vinicius N Brito; Ana Claudia Latronico
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