Ernestina Santos1,2, Ester Coutinho3, Isabel Moreira1, Ana Martins Silva1,2, Dina Lopes4, Henrique Costa5, Fernando Silveira5, Goreti Nadais5, Hugo Morais6, João Martins7, Maria Ceu Branco7,8, Andreia Veiga8, Rosa Santos Silva9, Augusto Ferreira10, Filipa Sousa11, Marta Freijo12, Ilda Matos12, Rui André13, Luís Negrão14, Carla Fraga15, Manuela Santos16, Mafalda Sampaio17, Carlos Lopes18, Maria Isabel Leite3, Guilherme Gonçalves2. 1. Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, Portugal. 2. Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal. 3. Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, University of Oxford, UK. 4. Centro Hospitalar do Porto, Porto, Portugal. 5. Neurology Department, Hospital Sao Joao, Porto, Portugal. 6. Neurology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Gaia, Portugal. 7. Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal. 8. Neurology Department, Hospital de Sao Pedro, Centro Hospitalar do Trás-os-Montes e Alto Douro, Vila Real, Portugal. 9. Neurology Department, Centro Hospitalar do Alto Minho, Viana do Castelo, Portugal. 10. Neurology Department, Centro Hospitalar Entre Douro e Vouga, Feira, Portugal. 11. Neurology Department, Hospital de Braga, Braga, Portugal. 12. Neurology Department, Centro Hospitalar do Nordeste, Mirandela, Portugal. 13. Neurology Department, Hospital de São Teotonio, Viseu, Portugal. 14. Neurology Department, Centro Hospitalar Universitario de Coimbra, Coimbra, Portugal. 15. Neurology Department, Centro Hospitalar do Vale do Sousa, Penafiel, Portugal. 16. Neuropediatrics Department, Centro Materno Infantil Norte, Centro Hospitalar Porto, Porto, Portugal. 17. Neuropediatrics Department, Hospital de Sao Joao, Porto, Portugal. 18. Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Abstract
INTRODUCTION: In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal and characterized the clinical features of the patients identified. METHODS: We used 2 data sources: clinical records from the hospitals and pyridostigmine prescription registers. RESULTS: On December 31, 2013, we estimated a point prevalence of 111.7 patients per million population. The highest prevalence was observed in the group >65 years of age, especially in men (288.1 per million). During 2013, we estimated an incidence rate of 6.3 per million per year. Among women, the incidence rate was highest in the 15-49-year age group; in men, incidence increased with age up to 22.1 per million in those >65 years old. The MG-related mortality rate was 0.5 per million. CONCLUSIONS: These figures are in keeping with similar studies and emphasize the importance of diagnosis and management of MG in elderly populations. Muscle Nerve 54: 413-421, 2016.
INTRODUCTION: In this study we estimated the prevalence, incidence, and mortality of myasthenia gravis (MG) in northern Portugal and characterized the clinical features of the patients identified. METHODS: We used 2 data sources: clinical records from the hospitals and pyridostigmine prescription registers. RESULTS: On December 31, 2013, we estimated a point prevalence of 111.7 patients per million population. The highest prevalence was observed in the group >65 years of age, especially in men (288.1 per million). During 2013, we estimated an incidence rate of 6.3 per million per year. Among women, the incidence rate was highest in the 15-49-year age group; in men, incidence increased with age up to 22.1 per million in those >65 years old. The MG-related mortality rate was 0.5 per million. CONCLUSIONS: These figures are in keeping with similar studies and emphasize the importance of diagnosis and management of MG in elderly populations. Muscle Nerve 54: 413-421, 2016.
Authors: Jason A Vander Heiden; Panos Stathopoulos; Julian Q Zhou; Luan Chen; Tamara J Gilbert; Christopher R Bolen; Richard J Barohn; Mazen M Dimachkie; Emma Ciafaloni; Teresa J Broering; Francois Vigneault; Richard J Nowak; Steven H Kleinstein; Kevin C O'Connor Journal: J Immunol Date: 2017-01-13 Impact factor: 5.422
Authors: John S Yi; Jeffrey T Guptill; Panos Stathopoulos; Richard J Nowak; Kevin C O'Connor Journal: Muscle Nerve Date: 2017-09-30 Impact factor: 3.217