Lubaba Shahrin1, Mohammad Jobayer Chisti2, Sayeeda Huq1, Thamanna Nishath3, Maria D Christy4, Anika Hannan5, Tahmeed Ahmed1. 1. Centre for Nutrition and Food Security (CNFS), International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, 1212 Bangladesh. 2. Centre for Nutrition and Food Security (CNFS), International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, 1212 Bangladesh chisti@icddrb.org. 3. Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, 22908 USA. 4. School of Nutrition and Health Promotion, Arizona State University, Tempe, AZ, 85004 USA. 5. University of North Carolina at Chapel Hill, Chapel Hill, NC, 28303 USA.
Abstract
OBJECTIVE: To study clinical manifestations and outcome of hyponatremia and hypernatremia in children with diarrhea. METHOD: We compared children aged 0-59 months hospitalized from 1 January to 31 December 2013 with hyponatremia (serum sodium <130 mmol/l), hypernatremia (serum sodium >150 mmol/l) and normonatremia (serum sodium 135-145 mmol/l). RESULTS: The case fatality was significantly higher among the children with hypernatremia and hyponatremia than normonatremia. A logistic regression analysis adjusting for potential confounders revealed that children with hyponatremia are more likely to have convulsions, have severe acute malnutrition and be of older age compared with children with normal serum sodium. Children with hypernatremia are more likely to have convulsions and dehydration than normonatremic children (for all p < 0.05). CONCLUSION: Early diagnosis and prompt management of hypo- and hypernatremia by identifying simple clinical predicting factors of these two conditions in diarrheal children <5 years of age is critically important to prevent deaths in such children, especially in resource-limited settings.
OBJECTIVE: To study clinical manifestations and outcome of hyponatremia and hypernatremia in children with diarrhea. METHOD: We compared children aged 0-59 months hospitalized from 1 January to 31 December 2013 with hyponatremia (serum sodium <130 mmol/l), hypernatremia (serum sodium >150 mmol/l) and normonatremia (serum sodium 135-145 mmol/l). RESULTS: The case fatality was significantly higher among the children with hypernatremia and hyponatremia than normonatremia. A logistic regression analysis adjusting for potential confounders revealed that children with hyponatremia are more likely to have convulsions, have severe acute malnutrition and be of older age compared with children with normal serum sodium. Children with hypernatremia are more likely to have convulsions and dehydration than normonatremic children (for all p < 0.05). CONCLUSION: Early diagnosis and prompt management of hypo- and hypernatremia by identifying simple clinical predicting factors of these two conditions in diarrheal children <5 years of age is critically important to prevent deaths in such children, especially in resource-limited settings.
Authors: Tahmina Alam; Tahmeed Ahmed; Monira Sarmin; Lubaba Shahrin; Farzana Afroze; Shamima Akhter; K M Shahunja; Abu Sadat Mohammad Sayeem Bin Shahid; Pradip Kumar Bardhan; Mohammod Jobayer Chisti Journal: Glob Pediatr Health Date: 2017-03-30
Authors: Lubaba Shahrin; Monira Sarmin; Abu Smmh Rahman; Waliel Hasnat; Gazi Ms Mamun; Shamsun N Shaima; Abu Smsb Shahid; Tahmeed Ahmed; Mohammod J Chisti Journal: J Int Med Res Date: 2020-01 Impact factor: 1.671