Nicholas K Reul1, Wenjin Li, Lisa G Gallagher, Roberta M Ray, Megan E Romano, Daoli Gao, David B Thomas, Sverre Vedal, Harvey Checkoway. 1. Department of Environmental and Occupational Health Sciences (Drs Gallagher, Vedal, and Checkoway); Department of Epidemiology (Drs Romano and Thomas), University of Washington; Program in Epidemiology (Drs Li and Thomas), Division of Public Health Sciences (Ms Ray), Fred Hutchinson Cancer Research Center, Seattle; Department of Epidemiology (Dr Gao), Zhongshan Hospital, Fu Dan University, Shanghai, China; and Department of Family and Preventive Medicine, University of California San Diego, La Jolla.
Abstract
OBJECTIVE: We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort. METHODS: We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design. RESULTS: We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals. CONCLUSIONS: Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.
OBJECTIVE: We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort. METHODS: We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design. RESULTS: We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals. CONCLUSIONS: Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.
Authors: Miguel Santibañez; Jesús Vioque; Juan Alguacil; Manuela García de la Hera; Eduardo Moreno-Osset; Alfredo Carrato; Miquel Porta; Timo Kauppinen Journal: Eur J Epidemiol Date: 2010-07-17 Impact factor: 8.082
Authors: George Astrakianakis; Noah S Seixas; Janice E Camp; David C Christiani; Ziding Feng; David B Thomas; Harvey Checkoway Journal: Ann Occup Hyg Date: 2006-04-21
Authors: R M Castellan; S A Olenchock; J L Hankinson; P D Millner; J B Cocke; C K Bragg; H H Perkins; R R Jacobs Journal: Ann Intern Med Date: 1984-08 Impact factor: 25.391
Authors: Ahmedin Jemal; Freddie Bray; Melissa M Center; Jacques Ferlay; Elizabeth Ward; David Forman Journal: CA Cancer J Clin Date: 2011-02-04 Impact factor: 508.702
Authors: W Li; R M Ray; D L Gao; E D Fitzgibbons; N S Seixas; J E Camp; K J Wernli; G Astrakianakis; Z Feng; D B Thomas; H Checkoway Journal: Occup Environ Med Date: 2006-07-17 Impact factor: 4.402