| Literature DB >> 26848504 |
Shu Nishikori, Kenji Takemoto, Shinji Kamisuki, Syo Nakajima1, Kouji Kuramochi2, Senko Tsukuda1, Masashi Iwamoto1, Yuri Katayama, Takahiro Suzuki, Susumu Kobayashi, Koichi Watashi1, Fumio Sugawara.
Abstract
New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A-C (1-3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinone/isoherqueinone (7/7a), were also obtained. The isolated compounds were tested for anti-hepatitis C virus (HCV) activity, and peniciherquamide C (3) was found to display an IC50 value of 5.1 μM. To our knowledge, this is the first report of a diazabicyclo[2.2.2]octane derivative with anti-HCV activity.Entities:
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Year: 2016 PMID： 26848504 DOI： 10.1021/acs.jnatprod.5b00555
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050