| Literature DB >> 26848110 |
Jie-Feng Tian1, Peng-Ju Li2, Xiao-Xia Li3, Ping-Hua Sun3, Hao Gao3, Xing-Zhong Liu4, Peng Huang5, Jin-Shan Tang6, Xin-Sheng Yao7.
Abstract
Eight new isocoumarin glycosides (1-8) were obtained from the solid culture of the wetland soil-derived fungus Metarhizium anisopliae (No. DTH12-10). Their chemical structures were elucidated by analyses of HR ESI-TOF MS, (1)H, (13)C NMR, (1)H-(1)H COSY, HSQC, and HMBC spectra. The absolute configurations were determined by single crystal X-ray diffraction, circular dichroism (CD) spectrum, and chemical derivatization methods. In addition, inhibition of the biofilm formation and the secretion of virulence factor of the new isocoumarin glycosides against Pseudomonas aeruginosa strain PAOA (clinical isolates) were evaluated. The result revealed that compound 1 showed antibacterial activity comparable with (Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BF).Entities:
Keywords: 3,4-Dihydroisocoumarin glycoside; Antibacterial activity; Biofilm inhibitory activity; Chemical constituents; Metarhizium anisopliae; Virulence factor secretion
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Year: 2016 PMID： 26848110 DOI： 10.1016/j.bmcl.2016.01.074
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823