| Literature DB >> 26847937 |
Sue Min Kim1, Yun Ho Kim1, Young Joon Jun2, Gyeol Yoo1, Jong Won Rhie3.
Abstract
To investigate whether diabetes mellitus affects the wound-healing-promoting potential of adipose tissue-derived stem cells, we designed a wound-healing model using diabetic mice. We compared the degree of wound healing between wounds treated with normal adipose tissue-derived stem cells and wounds treated with diabetic adipose tissue-derived stem cells. We evaluated the wound-healing rate, the epithelial tongue distance, the area of granulation tissue, the number of capillary and the number of Ki-67-stained cells. The wound-healing rate was significantly higher in the normal adipose tissue-derived stem cells group than in the diabetic adipose tissue-derived stem cells group; it was also significantly higher in the normal adipose tissue-derived stem cells group than in the control group. Although the diabetic adipose tissue-derived stem cells group showed a better wound-healing rate than the control group, the difference was not statistically significant. Similar trends were observed for the other parameters examined: re-epithelisation and keratinocyte proliferation; granulation tissue formation; and dermal regeneration. However, with regard to the number of capillary, diabetic adipose tissue-derived stem cells retained their ability to promote neovasculisation and angiogenesis. These results reflect the general impairment of the therapeutic potential of diabetic adipose tissue-derived stem cells in vivo.Entities:
Keywords: adipose tissue; adult stem cell; cell therapy; diabetes mellitus; wound healing
Mesh：
Year: 2016 PMID： 26847937 PMCID： PMC7949718 DOI： 10.1111/iwj.12540
Source DB: PubMed Journal: Int Wound J ISSN： 1742-4801 Impact factor: 3.315