Graziela Z Kalil1,2, Ana Recober3, Ann Hoang-Tienor3, Miriam Bridget Zimmerman4,5, William G Haynes2,6, Gary L Pierce1,6,7,8. 1. Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa, USA. 2. Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA. 3. Department of Neurology, University of Iowa, Iowa City, Iowa, USA. 4. Department of Biostatistics, University of Iowa, Iowa City, Iowa, USA. 5. Institute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, USA. 6. Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, USA. 7. UI Center for Hypertension Research, University of Iowa, Iowa City, Iowa, USA. 8. Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA.
Abstract
OBJECTIVE: Obesity is a major risk factor for chronic daily headaches, including migraine and tension-type headache (TTH). Although migraine is associated with increased risk of cardiovascular diseases (CVD), a relation between TTH and CVD risk has not been established. It was hypothesized that higher carotid-femoral pulse wave velocity (CFPWV) and augmentation index (AI), measures of aortic stiffness and pressure wave reflection, respectively, and biomarkers of CVD risk, would be higher among adults with obesity and migraine or TTH compared with those with no headache. METHODS: Adults with obesity (n = 93; body mass index ≥30 kg/m(2) ) who were between 40 and 75 years old with at least one additional CVD risk factor were enrolled. Subjects had CFPWV and AI assessed and a complete neurological exam for diagnosis of headache in the past 12 months. RESULTS: Adults with obesity and TTH (P = 0.018), but not migraine (P = 0.29), had significantly higher AI compared with those with no headache. When both CFPWV and AI were considered in a logistic regression model with migraine or TTH, only AI was associated with TTH (P = 0.008) and migraine (P = 0.032) but could not distinguish between the two headache phenotypes. CONCLUSIONS: Increased aortic AI but not stiffness is associated with TTH and migraine among middle-aged/older adults with obesity and high CVD risk.
OBJECTIVE:Obesity is a major risk factor for chronic daily headaches, including migraine and tension-type headache (TTH). Although migraine is associated with increased risk of cardiovascular diseases (CVD), a relation between TTH and CVD risk has not been established. It was hypothesized that higher carotid-femoral pulse wave velocity (CFPWV) and augmentation index (AI), measures of aortic stiffness and pressure wave reflection, respectively, and biomarkers of CVD risk, would be higher among adults with obesity and migraine or TTH compared with those with no headache. METHODS: Adults with obesity (n = 93; body mass index ≥30 kg/m(2) ) who were between 40 and 75 years old with at least one additional CVD risk factor were enrolled. Subjects had CFPWV and AI assessed and a complete neurological exam for diagnosis of headache in the past 12 months. RESULTS: Adults with obesity and TTH (P = 0.018), but not migraine (P = 0.29), had significantly higher AI compared with those with no headache. When both CFPWV and AI were considered in a logistic regression model with migraine or TTH, only AI was associated with TTH (P = 0.008) and migraine (P = 0.032) but could not distinguish between the two headache phenotypes. CONCLUSIONS: Increased aortic AI but not stiffness is associated with TTH and migraine among middle-aged/older adults with obesity and high CVD risk.
Authors: Seymour Diamond; Marcelo E Bigal; Stephen Silberstein; Elizabeth Loder; Michael Reed; Richard B Lipton Journal: Headache Date: 2007-03 Impact factor: 5.887
Authors: James E Sharman; Richard Lim; Ahmad M Qasem; Jeff S Coombes; Malcolm I Burgess; Jeff Franco; Paul Garrahy; Ian B Wilkinson; Thomas H Marwick Journal: Hypertension Date: 2006-05-01 Impact factor: 10.190
Authors: Yoav Ben-Shlomo; Melissa Spears; Chris Boustred; Margaret May; Simon G Anderson; Emelia J Benjamin; Pierre Boutouyrie; James Cameron; Chen-Huan Chen; J Kennedy Cruickshank; Shih-Jen Hwang; Edward G Lakatta; Stephane Laurent; João Maldonado; Gary F Mitchell; Samer S Najjar; Anne B Newman; Mitsuru Ohishi; Bruno Pannier; Telmo Pereira; Ramachandran S Vasan; Tomoki Shokawa; Kim Sutton-Tyrell; Francis Verbeke; Kang-Ling Wang; David J Webb; Tine Willum Hansen; Sophia Zoungas; Carmel M McEniery; John R Cockcroft; Ian B Wilkinson Journal: J Am Coll Cardiol Date: 2013-11-13 Impact factor: 24.094
Authors: Gary L Pierce; Graziela Z Kalil; Tiwaloluwa Ajibewa; Seth W Holwerda; Jane Persons; David J Moser; Jess G Fiedorowicz Journal: Obesity (Silver Spring) Date: 2016-12-21 Impact factor: 5.002