Literature DB >> 26847460

In vitro synergistic effects of chlorpromazine and sertraline in combination with amphotericin B against Cryptococcus neoformans var. grubii.

Luana Rossato1, Érico S Loreto2, Régis A Zanette3, Francieli Chassot4, Janio M Santurio2, Sydney H Alves4.   

Abstract

Cryptococcus neoformans is encapsulated yeast that causes cryptococcosis. The cryptococcal meningitis may cause neuropsychiatric symptoms. Here, we evaluated the in vitro activity of amphotericin B (AMB), chlorpromazine (CLOR), and sertraline (SERT) alone or in combination against clinical isolates of C. neoformans considering the capsular induction in vitro. Susceptibility tests were carried out using the broth microdilution method in accordance with the CLSI document M27-A3. The combination [CLOR + AMB] exhibited synergism for 50 and 67 % of strains before capsular induction (group I) and after capsular induction (group II), respectively. The combination [SERT + AMB] showed 60 % of synergism against the both groups. Antagonism was not observed. Our results show the therapeutic potential of chlorpromazine and sertraline in combination with amphotericin B against neurocryptococcosis.

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Year:  2016        PMID： 26847460     DOI： 10.1007/s12223-016-0449-8

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  41 in total

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3.  Inhibitory effects of chlorpromazine on Candida species.

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6.  Manic episode secondary to cryptococcal meningitis in a previously healthy adult.

Authors:  F Y Johnson; S Naraqi
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Authors:  John R Perfect; William E Dismukes; Francoise Dromer; David L Goldman; John R Graybill; Richard J Hamill; Thomas S Harrison; Robert A Larsen; Olivier Lortholary; Minh-Hong Nguyen; Peter G Pappas; William G Powderly; Nina Singh; Jack D Sobel; Tania C Sorrell
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  9 in total

1.  The Antidepressant Sertraline Induces the Formation of Supersized Lipid Droplets in the Human Pathogen Cryptococcus neoformans.

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Journal:  J Fungi (Basel)       Date:  2022-06-17

2.  Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial.

Authors:  Joshua Rhein; Kathy Huppler Hullsiek; Lillian Tugume; Edwin Nuwagira; Edward Mpoza; Emily E Evans; Reuben Kiggundu; Katelyn A Pastick; Kenneth Ssebambulidde; Andrew Akampurira; Darlisha A Williams; Ananta S Bangdiwala; Mahsa Abassi; Abdu K Musubire; Melanie R Nicol; Conrad Muzoora; David B Meya; David R Boulware
Journal:  Lancet Infect Dis       Date:  2019-08       Impact factor: 25.071

3.  In Vitro Antifungal Activity of Sertraline and Synergistic Effects in Combination with Antifungal Drugs against Planktonic Forms and Biofilms of Clinical Trichosporon asahii Isolates.

Authors:  Lin Cong; Yong Liao; Suteng Yang; Rongya Yang
Journal:  PLoS One       Date:  2016-12-08       Impact factor: 3.240

4.  The combination of tamoxifen with amphotericin B, but not with fluconazole, has synergistic activity against the majority of clinical isolates of Cryptococcus neoformans.

Authors:  Trieu Phan Hai; Anh Duong Van; Nguyen Thi Thuy Ngan; Le Thanh Hoang Nhat; Nguyen Phu Huong Lan; Nguyen V Vinh Chau; Guy E Thwaites; Damian Krysan; Jeremy N Day
Journal:  Mycoses       Date:  2019-06-23       Impact factor: 4.377

5.  Cryptococcosis today: It is not all about HIV infection.

Authors:  Jane A O'Halloran; William G Powderly; Andrej Spec
Journal:  Curr Clin Microbiol Rep       Date:  2017-04-17

Review 6.  Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi.

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Journal:  Pharmaceuticals (Basel)       Date:  2021-05-20

Review 7.  Drug repurposing strategies in the development of potential antifungal agents.

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8.  Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens.

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9.  In Vitro Activity of Sertraline, an Antidepressant, Against Antibiotic-Susceptible and Antibiotic-Resistant Helicobacter pylori Strains.

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Journal:  Pathogens       Date:  2019-11-10
  9 in total

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