Ki-Yong Ahn1, Mi Kyung Lee1, Dong-Il Kim1, Jihye Park1, Jihee Min1, Hyuk In Yang1, Junga Lee1, Minsuk Oh1, Joongbae An2, Ji-Won Lee3, Sang Hui Chu4, Jeffrey A Meyerhardt5, Nam-Kyu Kim6,7, Justin Y Jeon8,9. 1. Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea. 2. Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea. 3. Department of Family Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea. 4. Department of Clinical Nursing Science, Yonsei University, College of Nursing, Nursing Policy Research Institute, Biobehavioral Research Center, Seoul, Republic of Korea. 5. Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA. 6. Department of Surgery, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu, Seoul, 120-752, South Korea. namkyuk@yuhs.ac. 7. Department of Sport and Leisure Studies, Exercise Medicine Center for Diabetes and Cancer Patients, Yonsei University, Shinchon-dong, Seodaemun-gu, Seoul, 120-749, South Korea. namkyuk@yuhs.ac. 8. Cancer Prevention Center, Yonsei Cancer Canter, Department of Medicine, Yonsei Unversity College of Medicine, Yonsei University, Seoul, Republic of Korea. jjeon@yonsei.ac.kr. 9. Department of Sport and Leisure Studies, Exercise Medicine Center for Diabetes and Cancer Patients, Yonsei University, Shinchon-dong, Seodaemun-gu, Seoul, 120-749, South Korea. jjeon@yonsei.ac.kr.
Abstract
PURPOSE: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients. METHODS: A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. RESULT: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = -0.299, p = 0.002; β = -0.201, p = 0.033) were independently associated with fasting insulin level. CONCLUSION: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.
PURPOSE: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancerpatients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancerpatients. METHODS: A total of 123 stage II-III colorectal cancerpatients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. RESULT: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = -0.299, p = 0.002; β = -0.201, p = 0.033) were independently associated with fasting insulin level. CONCLUSION: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancerpatients by influencing physical fitness level, circulating levels of adiponectin and chemerin.
Authors: Josephina G Kuiper; Amanda I Phipps; Marian L Neuhouser; Rowan T Chlebowski; Cynthia A Thomson; Melinda L Irwin; Dorothy S Lane; Jean Wactawski-Wende; Lifang Hou; Rebecca D Jackson; Ellen Kampman; Polly A Newcomb Journal: Cancer Causes Control Date: 2012-10-02 Impact factor: 2.506
Authors: Brian M Wolpin; Jeffrey A Meyerhardt; Andrew T Chan; Kimmie Ng; Jennifer A Chan; Kana Wu; Michael N Pollak; Edward L Giovannucci; Charles S Fuchs Journal: J Clin Oncol Date: 2008-12-08 Impact factor: 44.544
Authors: Russell K Pachynski; Brian A Zabel; Holbrook E Kohrt; Nicole M Tejeda; Justin Monnier; Christina D Swanson; Alison K Holzer; Andrew J Gentles; Gizette V Sperinde; Abdolhossein Edalati; Husein A Hadeiba; Ash A Alizadeh; Eugene C Butcher Journal: J Exp Med Date: 2012-07-02 Impact factor: 14.307