Literature DB >> 2684690

Insulin stimulates the translocation of protein kinase C in rat adipocytes.

T Ishizuka1, D R Cooper, R V Farese.   

Abstract

Insulin-induced changes in protein kinase C were examined in cytosol and membrane fractions of rat adipocytes enzymatically after Mono Q column chromatography and by immunoblotting. During a 5-20 min period of insulin treatment, cytosolic protein kinase C decrease by approximately 50%, whereas membrane protein kinase C increased nearly 2-fold. These findings suggest that insulin stimulates the translocation of protein kinase C in rat adipocytes.

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Year:  1989        PMID： 2684690     DOI： 10.1016/0014-5793(89)81565-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

Review 1.  Specific protein kinase C isoforms as transducers and modulators of insulin signaling.

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2.  Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity.

Authors:  E K Tang; M D Houslay
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Review 3.  The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance.

Authors:  H U Häring
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Review 4.  Mechanisms of Insulin Action and Insulin Resistance.

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Journal:  Physiol Rev       Date:  2018-10-01       Impact factor: 37.312

5.  Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

Authors:  C Hu; S Pang; X Kong; M Velleca; J C Lawrence
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

6.  Gangliosides inhibit PDGF-induced signal transduction events in U-1242 MG human glioma cells.

Authors:  H E Saqr; J D Walters; Z Guan; B T Stokes; A J Yates
Journal:  Neurochem Res       Date:  1995-11       Impact factor: 3.996

7.  Tissue-dependent activation of protein kinase C in fructose-induced insulin resistance.

Authors:  R Donnelly; H Chang; S Azhar; G M Reaven
Journal:  Endocrine       Date:  1995-02       Impact factor: 3.633

8.  Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle.

Authors:  A Avignon; M L Standaert; K Yamada; H Mischak; B Spencer; R V Farese
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

9.  Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle and BC3H-1 myocytes.

Authors:  T P Arnold; M L Standaert; H Hernandez; J Watson; H Mischak; M G Kazanietz; L Zhao; D R Cooper; R V Farese
Journal:  Biochem J       Date:  1993-10-01       Impact factor: 3.857

10.  Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats.

Authors:  R V Farese; M L Standaert; K Yamada; L C Huang; C Zhang; D R Cooper; Z Wang; Y Yang; S Suzuki; T Toyota
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205
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