James Nataro1, O Colin Stine2. 1. Department of Pediatrics, University of Virginia, Charlottesville, VA. E-mail: jpn2r@virginia.edu. 2. Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD. E-mail: ostin001@umaryland.edu.
Dear Sir:We agree with Okeke and others1 that undiscovered enteroinvasive Escherichia coli (EIEC), as well as unidentified Shigella infections, may both account for the increased number of cases detected by Lindsay and others.2 However, we emphasize that the relative proportion of the two pathogens detected depends on the ipaH allele that is examined. The allele used by Lindsay and others2 is the same allele that was used by Sahl and others3; this allele resides on the Shigella chromosome and is not present in any EIEC isolates that have been sequenced to date (D. Rasko, unpublished data). We believe, therefore, that at least the majority of the excess detected cases are likely to be caused by Shigella spp.
Authors: Jason W Sahl; Carolyn R Morris; Jennifer Emberger; Claire M Fraser; John Benjamin Ochieng; Jane Juma; Barry Fields; Robert F Breiman; Matthew Gilmour; James P Nataro; David A Rasko Journal: J Clin Microbiol Date: 2015-01-14 Impact factor: 5.948
Authors: Brianna Lindsay; Debasish Saha; Doh Sanogo; Sumon Kumar Das; Richard Omore; Tamer H Farag; Dilruba Nasrin; Shan Li; Sandra Panchalingam; Myron M Levine; Karen Kotloff; James P Nataro; Laurence Magder; Laura Hungerford; A S G Faruque; Joseph Oundo; M Anowar Hossain; Mitchell Adeyemi; Oscar Colin Stine Journal: Am J Trop Med Hyg Date: 2015-08-31 Impact factor: 2.345