| Literature DB >> 26843382 |
Hussain Badani1, Teresa White1, Nicole Schulick1, Christopher D Raeburn2, Ibrahim Topkaya1, Don Gilden1,3, Maria A Nagel4.
Abstract
Varicella zoster virus (VZV) becomes latent in ganglionic neurons derived from neural crest cells. Because the adrenal gland also contains medullary chromaffin cells of neural crest origin, we examined human adrenal glands and medullary chromaffin cell tumors (pheochromocytomas) for VZV and herpes simplex virus type 1 (HSV-1). We found VZV, but not HSV-1, DNA in 4/63 (6 %) normal adrenal glands. No VZV transcripts or antigens were detected in the 4 VZV DNA-positive samples. No VZV or HSV-1 DNA was found in 21 pheochromocytomas.Entities:
Keywords: Adrenal gland; Latency; Pheochromocytoma; VZV
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Year: 2016 PMID： 26843382 PMCID： PMC5654543 DOI： 10.1007/s13365-016-0425-8
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643