| Literature DB >> 26842923 |
Jianming Tang1, Huijuan Shi1, Hui Li1, Tiantian Zhen1, Yu Dong1, Fenfen Zhang1, Yang Yang1, Anjia Han2.
Abstract
To clarify the clinicopathological and biological role of hepatoma-derived growth factor (HDGF) and β-catenin in synovial sarcoma. Our results showed that histological type and HDGF/β-catenin expression were the two important independent prognostic factors for overall survival in synovial sarcoma patients. HDGF knockdown dramatically inhibited cellular proliferation, colony formation, and migration but induced G1 phase arrest and apoptosis in SW982 cells. Recombinant HDGF enhanced synovial sarcoma cell growth and partially retrieved the cell growth suppression in SW982 cells upon HDGF knockdown. HDGF knockdown dramatically suppressed β-catenin and its downstream gene expression in SW982 cells. Intriguingly, β-catenin knockdown dramatically suppressed HDGF expression in SW982 cells. A direct interaction of HDGF and β-catenin was found in SW982 cells. Three HDGF-binding elements in β-catenin promoter were found and specific for transcriptional activation of β-catenin in SW982 cells. In conclusion, our findings first indicate that the interaction of HDGF and β-catenin may play a crucial role in tumorigenesis of synovial sarcoma.Entities:
Keywords: Hepatoma-derived growth factor; Synovial sarcoma; Tumorigenesis; β-Catenin
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Year: 2016 PMID： 26842923 DOI： 10.1007/s13277-016-4905-5
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283