| Literature DB >> 26842920 |
Merlin G Butler1, Jaehoon Lee2, Devin M Cox3, Ann M Manzardo3, June-Anne Gold4, Jennifer L Miller5, Elizabeth Roof6, Elisabeth Dykens6, Virginia Kimonis7, Daniel J Driscoll5.
Abstract
The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone-treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years. Anthropometric growth-related measures were obtained on 171 subjects with PWS who were treated with growth hormone for at least 40% of their lifespan. They had no history of scoliosis. PWS standardized growth curves were developed for 7 percentile ranges using the LMS method for weight, height, head circumference, weight/length, and BMI along with normative 3rd, 50th, and 97th percentiles plotted using control data from the literature and growth databases. Percentiles were plotted on growth charts for comparison purposes. Growth hormone treatment appears to normalize stature and markedly improves weight in PWS compared with standardized curves for non-growth hormone-treated PWS individuals. Growth chart implications and recommended usage are discussed.Entities:
Keywords: Prader-Willi syndrome; children; genetic subtype; growth hormone treatment; infants; standardized growth curves
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Year: 2016 PMID： 26842920 PMCID： PMC5922433 DOI： 10.1177/0009922815617973
Source DB: PubMed Journal: Clin Pediatr (Phila) ISSN： 0009-9228 Impact factor: 1.168