Zheng Zhao1, Yanyan Wang1, Zhiwei Guan2, Jingyu Jin1, Feng Huang1, Jian Zhu3. 1. Department of Rheumatology, PLA General Hospital, Beijing, China. 2. Department of Nuclear Medicine, PLA General Hospital, Beijing, China. 3. Department of Rheumatology, PLA General Hospital, Beijing, China. jian_jzhu@126.com.
Abstract
OBJECTIVES: The purpose of this work is to evaluate the usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging in management of IgG4-related disease (IgG4-RD) by retrospective analysis of PET/CT results in IgG4-RD patients. METHODS: Twenty-six patients diagnosed with IgG4-RD according to Japanese diagnostic criteria who underwent 18F-FDG-PET/CT scans in the PLA General Hospital from January 2010 to May 2015 were enrolled in the study. Their clinical presentations and 18F-FDG-PET/CT findings were analysed. RESULTS: A total of 26 patients (20 men; 6 women) with a mean age of 53.8 years (range 35-71 years) and mean treatment course of 7.1 months (range 0.33-72 months) who underwent 18F-FDG-PET/CT scans were analysed. CRP was relatively low in all patients (mean 0.79 mg/dl). 18F-FDG-PET/CT images confirmed that two or more organs were involved in all patients, and average SUV values for involved organs was 4.14 (range 0.30-8.78). Eleven patients were misdiagnosed with submandibular tumours, pancreatic cancer, pancreatitis, pulmonary interstitial fibrosis, retroperitoneal fibrosis or systemic vasculitis prior to 18F-FDG-PET/CT imaging. CONCLUSIONS: 18F-FDG-PET/CT imaging is a useful tool for the differential diagnosis of IgG4-RD, and for mapping involved organs, guiding biopsy, and monitoring treatment response.
OBJECTIVES: The purpose of this work is to evaluate the usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging in management of IgG4-related disease (IgG4-RD) by retrospective analysis of PET/CT results in IgG4-RD patients. METHODS: Twenty-six patients diagnosed with IgG4-RD according to Japanese diagnostic criteria who underwent 18F-FDG-PET/CT scans in the PLA General Hospital from January 2010 to May 2015 were enrolled in the study. Their clinical presentations and 18F-FDG-PET/CT findings were analysed. RESULTS: A total of 26 patients (20 men; 6 women) with a mean age of 53.8 years (range 35-71 years) and mean treatment course of 7.1 months (range 0.33-72 months) who underwent 18F-FDG-PET/CT scans were analysed. CRP was relatively low in all patients (mean 0.79 mg/dl). 18F-FDG-PET/CT images confirmed that two or more organs were involved in all patients, and average SUV values for involved organs was 4.14 (range 0.30-8.78). Eleven patients were misdiagnosed with submandibular tumours, pancreatic cancer, pancreatitis, pulmonary interstitial fibrosis, retroperitoneal fibrosis or systemic vasculitis prior to 18F-FDG-PET/CT imaging. CONCLUSIONS: 18F-FDG-PET/CT imaging is a useful tool for the differential diagnosis of IgG4-RD, and for mapping involved organs, guiding biopsy, and monitoring treatment response.
Authors: J-Matthias Löhr; Ulrich Beuers; Miroslav Vujasinovic; Domenico Alvaro; Jens Brøndum Frøkjær; Frank Buttgereit; Gabriele Capurso; Emma L Culver; Enrique de-Madaria; Emanuel Della-Torre; Sönke Detlefsen; Enrique Dominguez-Muñoz; Piotr Czubkowski; Nils Ewald; Luca Frulloni; Natalya Gubergrits; Deniz Guney Duman; Thilo Hackert; Julio Iglesias-Garcia; Nikolaos Kartalis; Andrea Laghi; Frank Lammert; Fredrik Lindgren; Alexey Okhlobystin; Grzegorz Oracz; Andrea Parniczky; Raffaella Maria Pozzi Mucelli; Vinciane Rebours; Jonas Rosendahl; Nicolas Schleinitz; Alexander Schneider; Eric Fh van Bommel; Caroline Sophie Verbeke; Marie Pierre Vullierme; Heiko Witt Journal: United European Gastroenterol J Date: 2020-06-18 Impact factor: 4.623
Authors: Yongzhu Pu; Chun Wang; Sheng Zhao; Ran Xie; Lei Zhao; Kun Li; Conghui Yang; Rui Zhang; Yadong Tian; Lixian Tan; Jindan Li; Shujuan Li; Long Chen; Hua Sun Journal: Transl Cancer Res Date: 2021-07 Impact factor: 1.241