Shih-Wei Lai1,2, Cheng-Li Lin1,3, Kuan-Fu Liao4,5,6. 1. College of Medicine, China Medical University, Taichung, Taiwan. 2. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan. 3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan. 4. College of Medicine, Tzu Chi University, Hualien, Taiwan. e-mail: kuanfuliaog@gmail.com. 5. Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan. e-mail: kuanfuliaog@gmail.com. 6. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. e-mail: kuanfuliaog@gmail.com.
Abstract
BACKGROUND: There is little data on the relationship between atrial fibrillation and acute pancreatitis. The aim of this study was to evaluate whether atrial fibrillation is associated with acute pancreatitis. METHODS: This retrospective cohort study analyzed the database of the Taiwan National Health Insurance Program from 2000 to 2010. There were 8,981 subjects aged 20-84 with newly diagnosed atrial fibrillation as the atrial fibrillation group and 26,643 sex- and age-matched, randomly selected subjects without atrial fibrillation as the non-atrial fibrillation group. We used the multivariable Cox proportional hazards regression model to measure the hazard ratio (HR) and 95% confidence interval (CI) for acute pancreatitis risk associated with atrial fibrillation and other comorbidities. RESULTS: The crude incidence rates of acute pancreatitis were 3.07 per 1,000 person-years in the atrial fibrillation group and 2.03 per 1,000 person-years in the non-atrial fibrillation group (incidence rate ratio 1.51, 95% CI 1.40, 1.63). After controlling for potential confounding factors, the adjusted HR of acute pancreatitis was 1.46 for the atrial fibrillation group, as compared with the non-atrial fibrillation group (95% CI 1.18, 1.80). In further analysis, even in the absence of alcohol-related disease and biliary stone, the adjusted HR of acute pancreatitis was 1.62 for the atrial fibrillation group, as compared with the non-atrial fibrillation group (95% CI 1.24, 2.12). CONCLUSIONS: Atrial fibrillation is associated with acute pancreatitis in the Taiwanese population, even in the absence of alcohol-related disease and biliary stone. Further research is necessary to explore the pathogenesis underlying the relationship between atrial fibrillation and acute pancreatitis.
BACKGROUND: There is little data on the relationship between atrial fibrillation and acute pancreatitis. The aim of this study was to evaluate whether atrial fibrillation is associated with acute pancreatitis. METHODS: This retrospective cohort study analyzed the database of the Taiwan National Health Insurance Program from 2000 to 2010. There were 8,981 subjects aged 20-84 with newly diagnosed atrial fibrillation as the atrial fibrillation group and 26,643 sex- and age-matched, randomly selected subjects without atrial fibrillation as the non-atrial fibrillation group. We used the multivariable Cox proportional hazards regression model to measure the hazard ratio (HR) and 95% confidence interval (CI) for acute pancreatitis risk associated with atrial fibrillation and other comorbidities. RESULTS: The crude incidence rates of acute pancreatitis were 3.07 per 1,000 person-years in the atrial fibrillation group and 2.03 per 1,000 person-years in the non-atrial fibrillation group (incidence rate ratio 1.51, 95% CI 1.40, 1.63). After controlling for potential confounding factors, the adjusted HR of acute pancreatitis was 1.46 for the atrial fibrillation group, as compared with the non-atrial fibrillation group (95% CI 1.18, 1.80). In further analysis, even in the absence of alcohol-related disease and biliary stone, the adjusted HR of acute pancreatitis was 1.62 for the atrial fibrillation group, as compared with the non-atrial fibrillation group (95% CI 1.24, 2.12). CONCLUSIONS:Atrial fibrillation is associated with acute pancreatitis in the Taiwanese population, even in the absence of alcohol-related disease and biliary stone. Further research is necessary to explore the pathogenesis underlying the relationship between atrial fibrillation and acute pancreatitis.
Authors: Maisam Abu-El-Haija; Soma Kumar; Jose Antonio Quiros; Keshawadhana Balakrishnan; Bradley Barth; Samuel Bitton; John F Eisses; Elsie Jazmin Foglio; Victor Fox; Denease Francis; Alvin Jay Freeman; Tanja Gonska; Amit S Grover; Sohail Z Husain; Rakesh Kumar; Sameer Lapsia; Tom Lin; Quin Y Liu; Asim Maqbool; Zachary M Sellers; Flora Szabo; Aliye Uc; Steven L Werlin; Veronique D Morinville Journal: J Pediatr Gastroenterol Nutr Date: 2018-01 Impact factor: 2.839