Jyh-Ming Jimmy Juang1, Ching-Yu Julius Chen1, Ying-Hsiang Chen2, I-Chien Wu2, Chih-Cheng Hsu2, Lei-Na Chen2, Feng-Cheng Tang3, Chi-Chung Wang4, Chung-Chou Juan5, Hou-Chang Chiu6, Huey-Ming Lo7, I-Shou Chang8, Juey-Jen Hwang1, Ling-Ping Lai1, Fu-Tien Chiang1, Jiunn-Lee Lin9, Chao Agnes Hsiung10. 1. Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 2. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. 3. Department of Occupational Medicine, Changhua Christian Hospotal, Taiwan. 4. Department of Family Medicine, Mennonite Christian Hospital, Taiwan. 5. Department of Surgery, Yuan's General Hospital, Taiwan. 6. Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan. 7. Section of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. 8. National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan. 9. Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan hsiung@nhri.org.tw jjmjuang@ntuh.gov.tw. 10. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan hsiung@nhri.org.tw jjmjuang@ntuh.gov.tw.
Abstract
AIMS: The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. METHODS AND RESULTS: The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). CONCLUSION: The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. METHODS AND RESULTS: The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). CONCLUSION: The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Gary Tse; Tong Liu; Ka H C Li; Victoria Laxton; Yin W F Chan; Wendy Keung; Ronald A Li; Bryan P Yan Journal: Front Physiol Date: 2016-10-18 Impact factor: 4.566