| Literature DB >> 26840751 |
Yunlong Yang1, Jieyuan Zhang2, Zhenzhen Liu1, Qiuning Lin1, Xiaolin Liu2, Chunyan Bao1, Yang Wang2, Linyong Zhu1.
Abstract
A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.Entities:
Keywords: hydrogels; imine crosslinking; o-nitrobenzene; photogelation; tissue integration
Mesh:
Substances:
Year: 2016 PMID: 26840751 DOI: 10.1002/adma.201505336
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849