PURPOSE: In 2015, a twenty-fold increase in the prevalence of microcephaly in Brazil was reported, and the Ministry of Health associated this abnormal prevalence with the maternal-fetal Zika virus (ZIKV) transmission. METHODS: We assessed the ophthalmological findings of ten mothers and their infants that had been clinically diagnosed with ZIKV-related microcephaly and presented ocular abnormalities, born from May to December 2015. RESULTS: Seven mothers (70.0%) referred symptoms during pregnancy (malaise, rash and arthralgia), of which six (85.7%) were in the first trimester. At the time of exam, no ophthalmological abnormalities were identified in the mothers and they did not report ocular symptoms during pregnancy. Serology was negative in all infants for Toxoplasmosis, Rubella, Cytomegalovirus, Syphilis and Human Immunodeficiency Viruses. Ocular findings included macular alterations (gross pigment mottling and/or chorioretinal atrophy) in fifteen eyes (75.0%), and optic nerve abnormalities (hypoplasia with double-ring sign, pallor, and/or increased cup-to-disk ratio) in nine eyes (45.0%). CONCLUSIONS: Patients presented normal anterior segment and important macular and optic nerve abnormalities. Further studies will assess the visual significance of these alterations.
PURPOSE: In 2015, a twenty-fold increase in the prevalence of microcephaly in Brazil was reported, and the Ministry of Health associated this abnormal prevalence with the maternal-fetal Zika virus (ZIKV) transmission. METHODS: We assessed the ophthalmological findings of ten mothers and their infants that had been clinically diagnosed with ZIKV-related microcephaly and presented ocular abnormalities, born from May to December 2015. RESULTS: Seven mothers (70.0%) referred symptoms during pregnancy (malaise, rash and arthralgia), of which six (85.7%) were in the first trimester. At the time of exam, no ophthalmological abnormalities were identified in the mothers and they did not report ocular symptoms during pregnancy. Serology was negative in all infants for Toxoplasmosis, Rubella, Cytomegalovirus, Syphilis and Human Immunodeficiency Viruses. Ocular findings included macular alterations (gross pigment mottling and/or chorioretinal atrophy) in fifteen eyes (75.0%), and optic nerve abnormalities (hypoplasia with double-ring sign, pallor, and/or increased cup-to-disk ratio) in nine eyes (45.0%). CONCLUSIONS:Patients presented normal anterior segment and important macular and optic nerve abnormalities. Further studies will assess the visual significance of these alterations.
Authors: Andrea A Zin; Irena Tsui; Julia Rossetto; Zilton Vasconcelos; Kristina Adachi; Stephanie Valderramos; Umme-Aiman Halai; Marcos Vinicius da Silva Pone; Sheila Moura Pone; Joel Carlos Barros Silveira Filho; Mitsue S Aibe; Ana Carolina C da Costa; Olivia A Zin; Rubens Belfort; Patricia Brasil; Karin Nielsen-Saines; Maria Elisabeth Lopes Moreira Journal: JAMA Pediatr Date: 2017-09-01 Impact factor: 16.193
Authors: Andrea A Zin; Irena Tsui; Julia D Rossetto; Stephanie L Gaw; Luiza M Neves; Olivia A Zin; Lorena Haefeli; Joel Carlos Barros Silveira Filho; Kristina Adachi; Marcos Vinicius da Silva Pone; Sheila Moura Pone; Natalia Molleri; Jose Paulo Pereira; Rubens Belfort; Vaithilingaraja Arumugaswami; Zilton Vasconcelos; Patricia Brasil; Karin Nielsen-Saines; Maria Elisabeth Lopes Moreira Journal: J AAPOS Date: 2018-10-22 Impact factor: 1.220