Anthony Faivre1, Emmanuelle Robinet2, Maxime Guye3, Celia Rousseau4, Adil Maarouf4, Arnaud Le Troter4, Wafaa Zaaraoui4, Audrey Rico2, Lydie Crespy5, Elisabeth Soulier4, Sylviane Confort-Gouny4, Jean Pelletier2, Sophie Achard6, Jean-Philippe Ranjeva4, Bertrand Audoin7. 1. CRMBM UMR AMU 7339, Faculté de Médecine, CNRS, Aix-Marseille Université, Marseille, France/Service de Neurologie, Hôpital d'Instruction des Armées Sainte-Anne, Toulon, France. 2. CRMBM UMR AMU 7339, Faculté de Médecine, CNRS, Aix-Marseille Université, Marseille, France/Service de Neurologie, Pôle de Neurosciences Cliniques, APHM, Hôpital de la Timone, Marseille, France. 3. CRMBM UMR AMU 7339, Faculté de Médecine, CNRS, Aix-Marseille Université, Marseille, France/CEMEREM, Pôle d'Imagerie Médicale, APHM, Hôpital de la Timone, Marseille, France. 4. CRMBM UMR AMU 7339, Faculté de Médecine, CNRS, Aix-Marseille Université, Marseille, France. 5. Service de Neurologie, Pôle de Neurosciences Cliniques, APHM, Hôpital de la Timone, Marseille, France. 6. UMR CNRS 5216, GIPSA, Saint Martin d'Hères, France. 7. CRMBM UMR AMU 7339, Faculté de Médecine, CNRS, Aix-Marseille Université, Marseille, France/Service de Neurologie, Pôle de Neurosciences Cliniques, APHM, Hôpital de la Timone, Marseille, France bertrand.audoin@ap-hm.fr.
Abstract
BACKGROUND: The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial. OBJECTIVE: To characterize the relationships between brain functional connectivity changes and disability progression in RRMS. METHODS: Long-range connectivity, short-range connectivity, and density of connections were assessed using graph theoretical analysis of resting-state functional magnetic resonance imaging (fMRI) data acquired in 38 RRMS patients (disease duration: 120 ± 32 months) and 24 controls. All subjects were explored at baseline and all patients and six controls 2 years later. RESULTS: At baseline, levels of long-range and short-range brain functional connectivity were higher in patients compared to controls. During the follow-up, decrease in connections' density was inversely correlated with disability progression. Post-hoc analysis evidenced differential evolution of brain functional connectivity metrics in patients according to their level of disability at baseline: while patients with lowest disability at baseline experienced an increase in all connectivity metrics during the follow-up, patients with higher disability at baseline showed a decrease in the connectivity metrics. In these patients, decrease in the connectivity metrics was associated with disability progression. CONCLUSION: The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression.
BACKGROUND: The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial. OBJECTIVE: To characterize the relationships between brain functional connectivity changes and disability progression in RRMS. METHODS: Long-range connectivity, short-range connectivity, and density of connections were assessed using graph theoretical analysis of resting-state functional magnetic resonance imaging (fMRI) data acquired in 38 RRMS patients (disease duration: 120 ± 32 months) and 24 controls. All subjects were explored at baseline and all patients and six controls 2 years later. RESULTS: At baseline, levels of long-range and short-range brain functional connectivity were higher in patients compared to controls. During the follow-up, decrease in connections' density was inversely correlated with disability progression. Post-hoc analysis evidenced differential evolution of brain functional connectivity metrics in patients according to their level of disability at baseline: while patients with lowest disability at baseline experienced an increase in all connectivity metrics during the follow-up, patients with higher disability at baseline showed a decrease in the connectivity metrics. In these patients, decrease in the connectivity metrics was associated with disability progression. CONCLUSION: The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression.
Authors: Shanna D Kulik; Ilse M Nauta; Prejaas Tewarie; Ismail Koubiyr; Edwin van Dellen; Aurelie Ruet; Kim A Meijer; Brigit A de Jong; Cornelis J Stam; Arjan Hillebrand; Jeroen J G Geurts; Linda Douw; Menno M Schoonheim Journal: Netw Neurosci Date: 2022-06-01
Authors: Sue-Jin Lin; Irene Vavasour; Brenda Kosaka; David K B Li; Anthony Traboulsee; Alex MacKay; Martin J McKeown Journal: Hum Brain Mapp Date: 2018-09-21 Impact factor: 5.038
Authors: Declan T Chard; Adnan A S Alahmadi; Bertrand Audoin; Thalis Charalambous; Christian Enzinger; Hanneke E Hulst; Maria A Rocca; Àlex Rovira; Jaume Sastre-Garriga; Menno M Schoonheim; Betty Tijms; Carmen Tur; Claudia A M Gandini Wheeler-Kingshott; Alle Meije Wink; Olga Ciccarelli; Frederik Barkhof Journal: Nat Rev Neurol Date: 2021-01-12 Impact factor: 42.937
Authors: Jan-Patrick Stellmann; Adil Maarouf; Karl-Heinz Schulz; Lisa Baquet; Jana Pöttgen; Stefan Patra; Iris-Katharina Penner; Susanne Gellißen; Gesche Ketels; Pierre Besson; Jean-Philippe Ranjeva; Maxime Guye; Guido Nolte; Andreas K Engel; Bertrand Audoin; Christoph Heesen; Stefan M Gold Journal: Front Hum Neurosci Date: 2020-06-30 Impact factor: 3.169