M J Mhanna1, A M Iqbal1, D C Kaelber1,2,3,4. 1. Departments of Pediatrics, Case Western Reserve University, The MetroHealth System, Cleveland, OH, USA. 2. Internal Medicine, Case Western Reserve University, The MetroHealth System, Cleveland, OH, USA. 3. Epidemiology and Biostatistics, Case Western Reserve University, The MetroHealth System, Cleveland, OH, USA. 4. Information Services, Case Western Reserve University, The MetroHealth System, Cleveland, OH, USA.
Abstract
OBJECTIVE: To determine the prevalence and weight gain as a risk factor of hypertension (HTN) at three years of age and older among extremely low birth weight (ELBW) infants. STUDY DESIGN: Retrospective cohort study of all ELBW infants born and followed up at our institution over 15 years. RESULTS: 204 infants were followed up for [median (inter-quartile range)] 10.2 years (6.9-13.0). Their birth weight and gestational age were (mean±standard deviation) 758±149 g and 26.4±2.1 weeks respectively. At 3 years of age and older, the prevalence of HTN was 7.3% (15/204), and the prevalence of obesity was 13.2% (27/204). Obesity was more prevalent in children with than without HTN [33% (5/15) vs. 12% (22/189); p = 0.01]. In a regression analysis, body mass index (BMI) percentile at 3 years of age and older (p = 0.04) and increase in weight Z scores since birth (p = 0.008) were associated with a higher systolic blood pressure (SBP; R = 0.386, p < 0.001). CONCLUSION: Obesity is prevalent in ELBW infants at three years of age and older, and it is significantly associated with hypertension. An increase in BMI percentile at ≥3 years of age, and the rate of weight gain since birth among ELBW infants are associated with an increase in SBP.
OBJECTIVE: To determine the prevalence and weight gain as a risk factor of hypertension (HTN) at three years of age and older among extremely low birth weight (ELBW) infants. STUDY DESIGN: Retrospective cohort study of all ELBW infants born and followed up at our institution over 15 years. RESULTS: 204 infants were followed up for [median (inter-quartile range)] 10.2 years (6.9-13.0). Their birth weight and gestational age were (mean±standard deviation) 758±149 g and 26.4±2.1 weeks respectively. At 3 years of age and older, the prevalence of HTN was 7.3% (15/204), and the prevalence of obesity was 13.2% (27/204). Obesity was more prevalent in children with than without HTN [33% (5/15) vs. 12% (22/189); p = 0.01]. In a regression analysis, body mass index (BMI) percentile at 3 years of age and older (p = 0.04) and increase in weight Z scores since birth (p = 0.008) were associated with a higher systolic blood pressure (SBP; R = 0.386, p < 0.001). CONCLUSION:Obesity is prevalent in ELBW infants at three years of age and older, and it is significantly associated with hypertension. An increase in BMI percentile at ≥3 years of age, and the rate of weight gain since birth among ELBW infants are associated with an increase in SBP.
Authors: Justin D Smith; Nivedita Mohanty; Matthew M Davis; Ashley A Knapp; Yacob G Tedla; Allison J Carroll; Heather E Price; Juan A Villamar; Roxane Padilla; Neil Jordan; C Hendricks Brown; Craig B Langman Journal: Implement Sci Commun Date: 2020-06-25
Authors: Dyah Kanya Wati; Putu Cintya Denny Yuliyatni; I Made Krisna Dinata; Gusti Ayu Putu Nilawati; I Gede Raka Widiana; Ida Bagus Ramajaya Sutawan; I Gusti Ngurah Putu Mandela Agatha Sunantara Journal: Open Access Maced J Med Sci Date: 2019-06-30