Literature DB >> 26835518

New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge.

Thomas R Hoye1, Walied M Alarif2, Salim S Basaif3, Mohamed Abo-Elkarm4, Mark T Hamann5, Amir E Wahba5, Seif-Eldin N Ayyad6.   

Abstract

Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

Entities:  

Keywords:  Plakortis sponge; cyclic peroxides; cytotoxicity; polyketides

Year:  2015        PMID： 26835518      PMCID： PMC4732738          DOI： 10.3998/ark.5550190.p008.948

Source DB:  PubMed          Journal:  ARKIVOC            Impact factor:   1.140


  2 in total

1.  Plakortides, novel cyclic peroxides from the sponge Plakortis halichondrioides: activators of cardiac SR-CA(2+)-pumping ATPase.

Authors:  A D Patil; A J Freyer; B Carte; R K Johnson; P Lahouratate
Journal:  J Nat Prod       Date:  1996-03       Impact factor: 4.050

2.  Antifungal peroxyketal acids from an Okinawan marine sponge of Plakortis sp.

Authors:  M Kobayashi; K Kondo; I Kitagawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  1993-07       Impact factor: 1.645
  2 in total
  3 in total

Review 1.  Recent trends in the structural revision of natural products.

Authors:  Bhuwan Khatri Chhetri; Serge Lavoie; Anne Marie Sweeney-Jones; Julia Kubanek
Journal:  Nat Prod Rep       Date:  2018-06-20       Impact factor: 13.423

2.  Sponge symbioses between Xestospongia deweerdtae and Plakortis spp. are not motivated by shared chemical defense against predators.

Authors:  Micah Jaarsma Marty; Jan Vicente; Benjamin L Oyler; Allen Place; Russell T Hill
Journal:  PLoS One       Date:  2017-04-18       Impact factor: 3.240

3.  Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.

Authors:  Tanja Schirmeister; Swarna Oli; Hongmei Wu; Gerardo Della Sala; Valeria Costantino; Ean-Jeong Seo; Thomas Efferth
Journal:  Mar Drugs       Date:  2017-03-03       Impact factor: 5.118
  3 in total

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