Cytochrome P-450 monooxygenases in insects.

1. The insect monooxygenase system is involved in the oxidative metabolism of both endogenous and exogenous substrates. 2. Monooxygenases appear to be important in insect growth and development, in adaptation to multiple food plants in phytophagous insects and in pesticide resistance. 3. The genetics, purification and properties of cytochrome P-450 isozymes of the house fly (Musca domestica) are discussed in relation to their role in resistance to xenobiotics. 4. Induction of insect cytochrome P-450 isozymes is discussed in comparison to induction in mammals and with reference to polyphagy.