| Literature DB >> 26834083 |
Manabu Hatano1, Katsuya Yamakawa1, Tomoaki Kawai1, Takahiro Horibe1, Kazuaki Ishihara2,3.
Abstract
A highly enantioselective cyanosilylation of ketones was developed by using a chiral lithium(I) phosphoryl phenoxide aqua complex as an acid/base cooperative catalyst. The pentacoordinate silicate generated in situ from Me3SiCN/LiCN acts as an extremely reactive cyano reagent. Described is a 30 gram scale reaction and the synthesis of the key precursor to (+)-13-hydroxyisocyclocelabenzine.Entities:
Keywords: asymmetric synthesis; homogeneous catalysis; ketones; lithium; silicates
Year: 2016 PMID： 26834083 DOI： 10.1002/anie.201510682
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336