Biqi Wang1, Wenjing Gao1, Jun Lv1, Canqing Yu1, Shengfeng Wang1, Zengchang Pang2, Liming Cong3, Zhong Dong4, Fan Wu5, Hua Wang6, Xianping Wu7, Guohong Jiang8, Xiaojie Wang9, Binyou Wang10, Weihua Cao1, Liming Li1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. 2. Qingdao Center for Diseases Control and Prevention, Qingdao, China. 3. Zhejiang Center for Disease Control and Prevention, Hangzhou, China. 4. Beijing Center for Disease Control and Prevention, Beijing, China. 5. Shanghai Center for Disease Control and Prevention, Shanghai, China. 6. Jiangsu Center for Disease Control and Prevention, Nanjing, China. 7. Sichuan Center for Disease Control and Prevention, Chengdu, China. 8. Tianjin Center for Disease Control and Prevention, Tianjin, China. 9. Qinghai Center for Disease Control and Prevention, Xining, China. 10. Harbin Medical University, Harbin, China.
Abstract
OBJECTIVE: This study aimed to examine the gene-environment interaction of physical activity and body mass index (BMI) using the Chinese National Twin Registry (CNTR). METHODS: A total of 19,308 same-sex adult twins from CNTR were included in the analysis. Twin zygosity was determined by self-reported questionnaire. Height and weight were measured using self-reported questionnaire. The vigorous physical activity was defined as greater or equal to five times a week of at least 30 min moderate- or high-intensity physical activity. A twin structural equation model was used to analyze the gene-environment interaction of vigorous exercise with BMI among 13,506 monozygotic twins and 5,802 dizygotic twins. RESULTS: A structural equation model adjusting for age and sex found vigorous exercise significantly moderated the additive genetic effects (P < 0.001) and shared environmental effects (P < 0.001) on BMI. The genetic contributions to BMI were significantly lower for people who adopted a physically active lifestyle [h(2) = 40%, 95% confidence interval (CI): 35%-46%] than those who were relative sedentary (h(2) = 59%, 95% CI: 52%-66%). The observed gene-physical activity interaction was more pronounced in men than women. CONCLUSIONS: Our results suggested that adopting a physically active lifestyle may help to reduce the genetic influence on BMI among the Chinese population.
OBJECTIVE: This study aimed to examine the gene-environment interaction of physical activity and body mass index (BMI) using the Chinese National Twin Registry (CNTR). METHODS: A total of 19,308 same-sex adult twins from CNTR were included in the analysis. Twin zygosity was determined by self-reported questionnaire. Height and weight were measured using self-reported questionnaire. The vigorous physical activity was defined as greater or equal to five times a week of at least 30 min moderate- or high-intensity physical activity. A twin structural equation model was used to analyze the gene-environment interaction of vigorous exercise with BMI among 13,506 monozygotic twins and 5,802 dizygotic twins. RESULTS: A structural equation model adjusting for age and sex found vigorous exercise significantly moderated the additive genetic effects (P < 0.001) and shared environmental effects (P < 0.001) on BMI. The genetic contributions to BMI were significantly lower for people who adopted a physically active lifestyle [h(2) = 40%, 95% confidence interval (CI): 35%-46%] than those who were relative sedentary (h(2) = 59%, 95% CI: 52%-66%). The observed gene-physical activity interaction was more pronounced in men than women. CONCLUSIONS: Our results suggested that adopting a physically active lifestyle may help to reduce the genetic influence on BMI among the Chinese population.
Authors: Dennis J Kerrigan; Margaret R Rukstalis; Jonathan K Ehrman; Steven J Keteyian; Ruicong She; Gwen L Alexander Journal: Clin Obes Date: 2019-03-25
Authors: Stephanie Schrempft; Cornelia H M van Jaarsveld; Abigail Fisher; Moritz Herle; Andrea D Smith; Alison Fildes; Clare H Llewellyn Journal: JAMA Pediatr Date: 2018-12-01 Impact factor: 16.193