Literature DB >> 26833154

Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model.

Cécile Vinot1, Jean-Marc Tréluyer2, Carole Giraud3, Laurent Gavard4, Gilles Peytavin5, Laurent Mandelbrot6.   

Abstract

Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26833154      PMCID： PMC4862479          DOI： 10.1128/AAC.00007-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  Pharmacokinetic and safety of raltegravir in pregnancy.

Authors:  Leonardo Croci; Michele Trezzi; Maria Pia Allegri; Tiziana Carli; Silvia Chigiotti; Maria Piera Riccardi; Barbara Ricciardi; Mario Toti; Cesira Nencioni
Journal:  Eur J Clin Pharmacol       Date:  2012-03-01       Impact factor: 2.953

2.  P-glycoprotein expression of the human placenta during pregnancy.

Authors:  S Gil; R Saura; F Forestier; R Farinotti
Journal:  Placenta       Date:  2005 Feb-Mar       Impact factor: 3.481

3.  Raltegravir concentrations in the genital tract of HIV-1-infected women treated with a raltegravir-containing regimen (DIVA 01 study).

Authors:  Cyril Clavel; Gilles Peytavin; Roland Tubiana; Cathia Soulié; Catherine Crenn-Hebert; Isabelle Heard; François Bissuel; Houria Ichou; Claudia Ferreira; Christine Katlama; Anne-Geneviève Marcelin; Laurent Mandelbrot
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

4.  Transfer across the perfused human placenta of antipyrine, sodium and leucine.

Authors:  H Schneider; M Panigel; J Dancis
Journal:  Am J Obstet Gynecol       Date:  1972-11-15       Impact factor: 8.661

5.  Raltegravir in HIV-1-Infected Pregnant Women: Pharmacokinetics, Safety, and Efficacy.

Authors:  Maren I Blonk; Angela P H Colbers; Carmen Hidalgo-Tenorio; Kabamba Kabeya; Katharina Weizsäcker; Annette E Haberl; José Moltó; David A Hawkins; Marchina E van der Ende; Andrea Gingelmaier; Graham P Taylor; Jelena Ivanovic; Carlo Giaquinto; David M Burger
Journal:  Clin Infect Dis       Date:  2015-05-05       Impact factor: 9.079

6.  Maternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model.

Authors:  F Forestier; P de Renty; G Peytavin; E Dohin; R Farinotti; L Mandelbrot
Journal:  Am J Obstet Gynecol       Date:  2001-07       Impact factor: 8.661

Review 7.  Novel integrase inhibitors for HIV.

Authors:  Nicole Prada; Martin Markowitz
Journal:  Expert Opin Investig Drugs       Date:  2010-09       Impact factor: 6.206

8.  Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011.

Authors:  Claire L Townsend; Laura Byrne; Mario Cortina-Borja; Claire Thorne; Annemiek de Ruiter; Hermione Lyall; Graham P Taylor; Catherine S Peckham; Pat A Tookey
Journal:  AIDS       Date:  2014-04-24       Impact factor: 4.177

9.  Short communication: Use of raltegravir in late-presenting HIV-infected pregnant women.

Authors:  Isabella Nóbrega; Ana Gabriela Travassos; Tatiana Haguihara; Fábio Amorim; Carlos Brites
Journal:  AIDS Res Hum Retroviruses       Date:  2013-06-25       Impact factor: 2.205

10.  The ex vivo human placental transfer of the anti-HIV nucleoside inhibitor abacavir and the protease inhibitor amprenavir.

Authors:  R E Bawdon
Journal:  Infect Dis Obstet Gynecol       Date:  1998
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  2 in total

1.  Placental transfer and tissue accumulation of dolutegravir in the ex vivo human cotyledon perfusion model.

Authors:  Laurent Mandelbrot; Pierre-François Ceccaldi; Dominique Duro; Minh Lê; Lucile Pencolé; Gilles Peytavin
Journal:  PLoS One       Date:  2019-08-13       Impact factor: 3.240

2.  Placental transfer of Letermovir & Maribavir in the ex vivo human cotyledon perfusion model. New perspectives for in utero treatment of congenital cytomegalovirus infection.

Authors:  Valentine Faure Bardon; Gilles Peytavin; Minh Patrick Lê; Tiffany Guilleminot; Elisabeth Elefant; Julien Stirnemann; Marianne Leruez-Ville; Yves Ville
Journal:  PLoS One       Date:  2020-04-30       Impact factor: 3.240
  2 in total

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