| Literature DB >> 26831779 |
Duygu Aydın Tekdaş1, Geetha Viswanathan2, Sevinc Zehra Topal1, Chung Yeng Looi3, Won Fen Wong4, Grace Min Yi Tan4, Yunus Zorlu1, Ayşe Gül Gürek1, Hong Boon Lee2, Fabienne Dumoulin1.
Abstract
A novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.Entities:
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Year: 2016 PMID： 26831779 DOI： 10.1039/c5ob02477c
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876